The Indian Journal of Pediatrics

, Volume 68, Issue 10, pp 927–929

Non-polio enteroviruses in acute flaccid paralysis

Original Article

Abstract

Objective Human enteroviruses are the major cause of aseptic meningitis and also cause a wide range of other acute illnesses, including neonatal sepsis like disease, meningitis, acute flaccid paralysis and acute hemorrhagic conjunctivitis. Infection in neonates is particularly life threatening.Methods : Stool samples of 523 children (age < 4 years) showing symptoms of acute flaccid paralysis (AFP) were studied. National Polio Surveillance Project workers from different parts of Uttar Pradesh and Bihar collected the samples during June to October 1998. Non-polio enteroviruses (NPEV) were isolated in 191 cases only, by cell culture based neutralization assay. These NPEV isolates were further studied to find the frequent enterovirus serotype detected in stool of children having AFP.Result : Data generated will help future studies on NPEV serotypes circulating in this area.Conclusion : In addition it may reduce unnecessary hospitalization, allow immune globulin batches of high titres to frequently circulating serotypes, to be reserved for intravenous therapy of neonates and guide the formulation of antigens for rapid and less expensive diagnosis.

Key words

Enterovirus Acute Flaccid Paralysis 

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References

  1. 1.
    Melnick JL. Enteroviruses: polioviruse, coxsackie viruses, echoviruses and newer enteroviruses. In BN Fields, DM Knipe, PM Howley, RM Chanock, JL Melinick, TP Monathet al, eds.Virology. 3rd edn. Lippencott-Raven, Philadelphia, Pa, 1996; 655–712.Google Scholar
  2. 2.
    Grist NR, Bell EJ, Assad F. Enteroviruses in human disease.Prog Med Virol 1978; 24: 114–157.PubMedGoogle Scholar
  3. 3.
    Landsdown ABG. Viral infections and disease of the heart.Prog Med Virol 1978; 24: 70–113.Google Scholar
  4. 4.
    Bowles NE, Richardson PJ, Olsen EGJ, Archard LC. Detection of coxsackie B virus specific RNA sequences in mycocardial biopsy samples from patients with myocarditis and dilated myocardiopathy.Lancet 1986; 1: 1120–1123.PubMedCrossRefGoogle Scholar
  5. 5.
    Yoon JW. The role of viruses and environmental factors in the induction of diabetes.Curr Top Microbiol Immunol 1990; 164: 95–123.PubMedGoogle Scholar
  6. 6.
    Chonmaitree T, Baldwin CD, Lucia HL. Role of virology laboratory in diagnosis and management in patients with central nervous system disease.Cli Micrbiol Rev 1989; 2: 1–14.Google Scholar
  7. 7.
    Kew OM, Mulders MN, Lipskaya GY, Dasilva EE, Pallansch MA. Molecular epidemiology of polioviruses.Semin Virol 1995;6: 401–414.CrossRefGoogle Scholar
  8. 8.
    Abzug MJ, Keyserling HL, Lee ML, Levin MJ, Robart HA. Neonatal enterovirus infections: virology, serology and effects of intravenous immunoglobulin.Clin Infect Dis 1995; 20: 1202–1206.Google Scholar
  9. 9.
    Wood DJ, Hull B. L20B cells simplify culture of polioviruses from clinical samples.J Med Virol 1999; 58: 188–192.PubMedCrossRefGoogle Scholar
  10. 10.
    Expanded Programme on Immunization. 1997 Mannual for the virological investigation of Polio. WHO/EPI/GEN/97.01 Geneva, Switzerland: World Health Organization.Google Scholar
  11. 11.
    Schmidt NJ, Melnick JL, Wenner HA, Ho HH, Burkhardt MA. Evaluation of enterovirus immune horse serum pools for identification of virus field strains.WHO Bull 1971; 45: 317–322.Google Scholar
  12. 12.
    Oostvogel PM, Conyn-van Spaendonck MAE, Hirasing RA, Van Loon AM. Surveillance of acute flaccid paralysis in the Netherlands, 1992-98.WHO Bull 1998; 76: 55–62.Google Scholar
  13. 13.
    Melnick JL. Enterovirus type 71 infections: a varied clinical pattern sometimes mimicking paralytic poliomyelitis.Rev Infect Vis 1984; 6 (S-2): S387-S390.Google Scholar
  14. 14.
    Hayward JCet al. Outbreak of poliomyelitis-like paralysis associated with enterovirus 71.Pediat Infect Dis J 1989; 8: 611–616.CrossRefGoogle Scholar
  15. 15.
    Assaad F, Cockburn WC. Four-year study of WHO virus reports on enteroviruses other than poliovirus.WHO Bull 1972; 46: 329–336.Google Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2001

Authors and Affiliations

  1. 1.Department of MicrobiologySanjay Gandhi Post Graduate Institute of Medical SciencesLucknowIndia

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