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Somatic Cell and Molecular Genetics

, Volume 23, Issue 3, pp 221–223 | Cite as

Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4

  • Robin M. Jones
  • Marcy E. MacDonald
  • John Branda
  • Michael R. Altherr
  • David N. Louis
  • Emmett V. Schmidt
Brief Communication

Abstract

We recently cloned genomic sequences containing the promoter region for the messenger RNA cap binding protein (eIF4E). As the rate-limiting step in translation, eukaryotic initiation factor 4E is important in cellular growth control. Using oligonucleotide primers specific for the promoter region in polymerase chain reactions (PCR), we amplified the human gene in a chromosome 4-specific human/rodent somatic cell panel. This panel mapped single copy genomic sequences for eIF4E in the region 4q21 to 4q25.

Keywords

Polymerase Chain Reaction Acute Myeloid Leukemia Polymerase Chain Reaction Analysis Somatic Cell Hybrid Panel Specific Malignancy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Robin M. Jones
    • 1
    • 2
  • Marcy E. MacDonald
    • 3
  • John Branda
    • 1
  • Michael R. Altherr
    • 4
  • David N. Louis
    • 5
  • Emmett V. Schmidt
    • 1
    • 2
  1. 1.Massachusetts General Hospital Cancer CenterCharlestown
  2. 2.The Children’s ServiceMassachusetts General HospitalBoston
  3. 3.Molecular Neurogenetics UnitMassachusetts General HospitalCharlestown
  4. 4.Genomics and Structural Biology GroupLos Alamos National LaboratoryLos Alamos
  5. 5.Department of PathologyMassachusetts General HospitalBoston

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