Journal of Thermal Analysis and Calorimetry

, Volume 51, Issue 1, pp 151–160 | Cite as

Hemolytic activity of a dental adhesive monomer and its interaction with dipalmitoyl phosphatidylcholine liposome

NMR and DSC measurements
  • S. Fujisawa
  • Y. Kadoma
Article

Abstract

To clarify the mechanism of the hemolytic activity of 4-META− (4-methacryloyloxyethyl trimellitate anhydride), an evaluation of the interaction of 4-META and its related compounds (4-MET; phthalic anhydride, PAN; and phthalic acid, PA) with DPPC liposomes using a DSC and NMR spectroscopy is presented.

Changes in NMR chemical shifts, phase transition temperatures and broadening of the main transition induced by 4-META and PAN were greater than those induced by 4-MET and PA. The order of decreasing interactions is as follows: 4-META>PAN>4-MET>PA.

Ionized compounds such as 4-MET and PA did not interact with erythrocyte membranes.

Keywords

DSC heat capacities hemolytic activity interaction 4-META NMR phospholipid liposomes 
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Copyright information

© Akadémiai Kiadó 1998

Authors and Affiliations

  • S. Fujisawa
    • 1
  • Y. Kadoma
    • 1
    • 2
  1. 1.School of DentistryMeikai UniversitySaitama-Ken
  2. 2.Institute for Medical and Dental EngineeringTokyo Medical and Dental University Kanda-surugadaiTokyoJapan

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