Intraamniotic infection with fusobacteria

  • W. Chaim
  • M. Mazor


A literature search produced ten studies in which Fusobacterium was cultured from amniotic fluid in women with preterm labor and intact membranes or with preterm premature rupture of membranes (PROM). Fusobacterium was isolated in 9.9% (9/91) of positive amniotic fluid cultures in women with preterm PROM and in 28.3% (17/60) of positive amniotic fluid cultures in women presenting with preterm labor and intact membranes. Fusobacterium plays a previously unrecognized role in the pathogenesis of premature labor and delivery. Amniotic fluid culture for anaerobs, specifically Fusobacterium, is suggested for all women who present with premature labor and intact membranes and do not respond to tocolytic drugs.

Key words

Intraamniotic infection Fusobacterium Preterm labor Premature rupture of membranes 


  1. 1.
    Altshuler G, Hyde S (1988) Clinicopathologic considerations of fusobacteria chorioamnionitis. Acta Obstet Gynecol Scand 67:513–517PubMedGoogle Scholar
  2. 2.
    Bobitt JR, Ledger WJ (1977) Unrecognized amnionitis and prematurity: a preliminary report. J Reprod Med 19:8–10PubMedGoogle Scholar
  3. 3.
    Bartlett JG, Polk BF (1984) Bacterial flora of the vagina: quantitative study. Rev Infect Dis 6:567–572Google Scholar
  4. 4.
    Bejar R, Curbelo V, Davis C et al. (1981) Premature labor: II. Bacterial sources of phospholipase. Obstet Gynecol 57:479–482PubMedGoogle Scholar
  5. 5.
    Cotton DB, Hill LM, Strassner HT, et al. (1984) Use of amniocentesis in preterm gestation with ruptured membranes. Obstet Gynecol 63:38–43PubMedGoogle Scholar
  6. 6.
    Easterling TR, Garite TJ (1985) Fusobacterium: anaerobic occult amnionitis and premature labor. Obstet Gynecol 66:825–828PubMedGoogle Scholar
  7. 7.
    Garite TJ, Freeman RK (1982) Chorioamnionitis in the preterm gestation. Obstet Gynecol 59:539–545PubMedGoogle Scholar
  8. 8.
    Gravett MG, Hummel D, Eschenbach DA, Holmes KK (1986) Preterm labor associated with subclinical amniotic fluid infection and with bacterial vaginosis. Obstet Gynecol 67:229–237PubMedCrossRefGoogle Scholar
  9. 9.
    Gibbs RS, Blanco JD, St Clair PJ, Castaneda YS (1982) Quantitative bacteriology of amniotic fluid from women with clinical intraamniotic infection at term. J Infect Dis 145:1–8PubMedGoogle Scholar
  10. 10.
    Gibbs RS, Blanco JD, Lipscomb K, St Clair PJ (1985) Asymptomatic parturient women with high-virulence bacteria in the amniotic fluid. Am J Obstet Gynecol 152:650–654PubMedGoogle Scholar
  11. 11.
    Ledger WJ (1989) Infection and premature labor. Am J Perinatol 6:234–236PubMedCrossRefGoogle Scholar
  12. 12.
    Leigh J, Garite TJ (1986) Amniocentesis and the management of premature labor. Obstet Gynecol 67:500–506PubMedGoogle Scholar
  13. 13.
    Larroche JCl, Helffer GP, Beaudoin M (1981) Bacteroides fragilis. Contamination maternoplacento-foetale. Arch Fr Pediatr 38:41–45PubMedGoogle Scholar
  14. 14.
    Levison ME, Cornman LC, Carrington ER, Kaye D (1977) Quantitative microflora of the vagina. Am J Obstet Gynecol 127:80–85PubMedGoogle Scholar
  15. 15.
    Lamont RF, Rose M, Elder MG (1985) Effect of bacterial products on prostaglandin E production by amnion cells. Lancet II:1331–1333CrossRefGoogle Scholar
  16. 16.
    Minkoff H (1983) Prematurity: infection as an etiologic factor. Obstet Gynecol 62:137–144PubMedGoogle Scholar
  17. 17.
    Miller JM, Pupkin MJ, Hill GB (1980) Bacterial colonization of amniotic fluid from intact fetal membranes. Am J Obstet Gynecol 136:796–804PubMedGoogle Scholar
  18. 18.
    Romero R, Mazor M (1988) Infection and preterm labor. Clin Obstet Gynecol 31:553–584PubMedCrossRefGoogle Scholar
  19. 19.
    Romero R, Mazor M, Oyarzun E (1988) Role of intraamniotic infection in preterm labor. Contemporary Obstet Gynecol 2:84–106Google Scholar
  20. 20.
    Romero R, Quintero R, Oyarzun E et al. (1988) Intraamniotic infection and the onset of labor in premature rupture of membranes. Am J Obstet Gynecol 159:661–666PubMedGoogle Scholar
  21. 21.
    Romero R, Sirtori M, Oyarzun E et al. (1989) Infection and Labor. V. Prevalence, microbiology and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 161:817–824PubMedGoogle Scholar
  22. 22.
    Ryan KJ (1984) Clostridia, gram negative anaerobes and anaerobic cocci. In: Sherris JC (ed) Medical microbiology, an introduction to infectious diseases. Elsevier, Amsterdam, pp 200–204Google Scholar
  23. 23.
    Romero R, Emamian M, Quintero R et al. (1986) Amniotic fluid prostaglandin levels and intraamniotic infections. Lancet II:1380CrossRefGoogle Scholar
  24. 24.
    Romero R, Oyarzun E, Mazor M (1989) Mechanism at work when infection triggers preterm labor. Contemporary Obstet Gynecol 1:2–10Google Scholar
  25. 25.
    Skoll MA, Moretti ML, Sibai BM (1989) The incidence of positive amniotic fluid cultures in patients in preterm labor with intact membranes. Am J Obstet Gynecol 161:813–816PubMedGoogle Scholar
  26. 26.
    Wallace RL, Herrick CN (1981) Amniocentesis in the evaluation of premature labor. Obstet Gynecol 57:483–486PubMedGoogle Scholar
  27. 27.
    Wahbeh CJ, Hill GB, Eden RD, Gall SA (1984) Intraamniotic bacterial colonization in premature labor. Am J obstet Gynecol 148:739–743PubMedGoogle Scholar
  28. 28.
    Weible DR, Randall HW (1985) Evaluation of amniotic fluid in preterm labor with intact membranes. J Reprod Med 30:777–780PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • W. Chaim
    • 1
    • 2
  • M. Mazor
    • 1
    • 2
  1. 1.Division of Obstetrics and GynecologySoroka Medical Center
  2. 2.the Faculty of Health SciencesBen Gurion University of the NegevBeer-ShevaIsrael

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