Lung

, Volume 168, Supplement 1, pp 720–725

Activation of natural killer cells and cytokine production in humans by bacterial extracts (OM-85 BV)

  • J. Wybran
  • M. Libin
  • L. Schandene
The Local Pulmonary Defense System: Activity Of Bacterial Fractions

Abstract

The influence of Broncho-Vaxom (BV) on different immune parameters was investigated in vitro on human peripheral blood mononuclear cells (PBMC). It was found that BV enhances the natural killer (NK) activity of PBMC and increases their spontaneous and phytohemagglutin (PHA)-induced production of tumor-necrosis factor—α and interleukin-2 as well as the PHA-stimulated production of interferon-γ. These immunostimulating actions of BV on NK activity and cytokine production can contribute to the understanding of the enhancement of the body’s defense mechanisms against respiratory tract infections.

Key words

Immunotherapy Broncho-Vaxom Natural killer Interferon Tumor-necrosis factor Interleukin In vitro 

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Copyright information

© Springer-Verlag New York Inc 1990

Authors and Affiliations

  • J. Wybran
    • 1
  • M. Libin
    • 1
  • L. Schandene
    • 1
  1. 1.Department of Immunology, Hematology, and Transfusion, Hôpital ErasmeUniversité Libre de BruxellesBrusselsBelgium

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