Journal of Biosciences

, Volume 6, Issue 6, pp 811–816 | Cite as

Increased circulatory half-life of liposomes after conjunction with dextran

  • D. Pain
  • P. K. Das
  • P. Ghosh
  • B. K. Bachhawat


Dextran was covalently coupled to neutral unilamellar liposomes. Dextran conjugated liposomes were cleared from the circulation at a much slower rate than unconjugated liposomes. The uptake of dextran conjugated liposomes by liver and spleen was also decreased. The amount of dextran on the surface of liposomes was found to be a determining factor for their stability in circulation. Dextran conjugated liposomes therefore may be a more effective way of controlled drug release


Unilamellar liposomes dextran conjugate drug delivery 

Abbreviations used




egg lecithin




concanavalin A


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Copyright information

© Indian Academy of Sciences 1984

Authors and Affiliations

  • D. Pain
    • 1
  • P. K. Das
    • 1
    • 2
  • P. Ghosh
    • 1
    • 3
  • B. K. Bachhawat
    • 1
  1. 1.Indian Institute of Chemical BiologyCalcuttaIndia
  2. 2.Developmental and Metabolic Neurology BranchNational Institutes of HealthBethesdaUSA
  3. 3.Department of MicrobiologyUniformed Services University Health SciencesBethesdaUSA

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