Increased circulatory half-life of liposomes after conjunction with dextran
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Abstract
Dextran was covalently coupled to neutral unilamellar liposomes. Dextran conjugated liposomes were cleared from the circulation at a much slower rate than unconjugated liposomes. The uptake of dextran conjugated liposomes by liver and spleen was also decreased. The amount of dextran on the surface of liposomes was found to be a determining factor for their stability in circulation. Dextran conjugated liposomes therefore may be a more effective way of controlled drug release
Keywords
Unilamellar liposomes dextran conjugate drug deliveryAbbreviations used
- Chol
Chlesterol
- EL
egg lecithin
- PE
phosphatidylethanolamine
- ConA
concanavalin A
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© Indian Academy of Sciences 1984