Clinical and Translational Oncology

, Volume 7, Issue 8, pp 332–335

Erythropoietin in cancer treatment: Considerations about Henke’s article

  • Alberto Biete Sola
  • Felipe A. Calvo Manuel
  • Bernardino Clavo Varas
  • Cristina Fernández Pérez
  • Carmen Porto Vázquez
  • Alejandro de la Torre Tomás
  • Almudena Zapatero Laborda
Special Article

DOI: 10.1007/BF02716548

Cite this article as:
Sola, A.B., Manuel, F.A.C., Varas, B.C. et al. Clin Transl Oncol (2005) 7: 332. doi:10.1007/BF02716548

Abstract

The concurrent use of erythropoietin beta (EPO) and radiotherapy in head and neck cancer patients has been reported by Henke et al (Lancet 2003; 362:1255–60) to correct anemia and impair cancer control. Due to the potential impact in daily clinical practice of this information a systematic critical review of the mentioned article was performed. Authors selected 10 arguments to question the contents regarding methodological and statistical aspects of the trial, and added 14 comments of controversy in more basic scientific concepts mentioned in the text as published. The panel including epidemiologist and radiation oncologists with expertise in clinical research concluded with 5 additional remarks recommending caution in interpretation of these results in terms of changes in daily practice of anemic patients support and advising not to use EPO at experimental doses or after reaching physiological concentrations of hemoglobin.

Key words

erythropoietin radiotherapy head and neck cancer 

Copyright information

© FESEO 2005

Authors and Affiliations

  • Alberto Biete Sola
    • 1
    • 2
  • Felipe A. Calvo Manuel
    • 1
    • 3
  • Bernardino Clavo Varas
    • 1
    • 4
  • Cristina Fernández Pérez
    • 5
  • Carmen Porto Vázquez
    • 6
  • Alejandro de la Torre Tomás
    • 1
    • 7
  • Almudena Zapatero Laborda
    • 1
    • 8
  1. 1.GICOR: Grupo de Investigación Clínica en Oncología RadioterápicaServicios de Oncología RadioterápicaMadridSpain
  2. 2.Hospital Clinic i ProvincialBarcelonaSpain
  3. 3.Hospital General Gregorio MarañónMadridSpain
  4. 4.Hospital Dr. NegrínLas PalmasSpain
  5. 5.Hospital Clínico San CarlosMadridSpain
  6. 6.Hospital General de GaliciaLa CoruñaSpain
  7. 7.Hospital Puerta de HierroMadridSpain
  8. 8.Hospital Universitario la PrincesaMadridSpain

Personalised recommendations