Lung

, Volume 161, Issue 1, pp 123–130 | Cite as

Relaxation of human isolated pulmonary arteries by prostacyclin (PGI2)

  • P. Hadházy
  • E. S. Vizi
  • K. Magyar
  • L. A. Debreczeni
  • I. Hutás
Original Articles
Accepted:

Abstract

The effects of indomethacin (IND) and PGI2 on the tone of human isolated pulmonary arteries were studied. Baseline tone of the vessels was increased by IND, electric stimulation (ES), norepinephrine (NE), prostaglandin F2α (PDF2α) or K+-excess. This high tone was decreased by PGI2 in a concentration dependent manner. IC50 values (molar concentrations producing 50% relaxation) for PGI2 were in the same concentration range (10 to 58.8 nmoles/l). The potency of the relaxant effect of PGI2 was inversely related to the magnitude of tone induced prior to the addition of PGI2 and independent of the type of tone inducer. It is suggested that the relaxant effect of prostacyclin on human pulmonary artery may be of clinical importance in the treatment of conditions associated with a rise in pulmonary vascular resistance.

Key words

Pulmonary artery Pulmonary vasodilatation Prostacyclin Indomethacin 
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Copyright information

© Springer-Verlag GmbH & Co KG 1983

Authors and Affiliations

  • P. Hadházy
    • 1
  • E. S. Vizi
    • 2
  • K. Magyar
    • 1
  • L. A. Debreczeni
    • 3
  • I. Hutás
    • 3
  1. 1.Department of PharmacodynamicsSemmelweis University of MedicineBudapest
  2. 2.Institute of Experimental MedicineHungarian Academy of SciencesBudapest
  3. 3.Respiratory Care and Clinical Pharmacological UnitNational Korányi Institute for TBC and PulmonologyBudapestHungary

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