Journal of Biosciences

, Volume 31, Issue 5, pp 575–579

Vitamin C improves basal metabolic rate and lipid profile in alloxan-induced diabetes mellitus in rats

  • D. U. Owu
  • A. B. Antai
  • K. H. Udofia
  • A. O. Obembe
  • K. O. Obasi
  • M. U. Eteng


Diabetes mellitus (DM) is a multi-factorial disease which is characterized by hyperglycaemia, lipoprotein abnormalities and oxidative stress. This study evaluated effect of oral vitamin C administration on basal metabolic rate and lipid profile of alloxan-induced diabetic rats. Vitamin C was administered at 200 mg/kg body wt. by gavage for four weeks to diabetic rats after which the resting metabolic rate and plasma lipid profile was determined. The results showed that vitamin C administration significantly (P<0.01) reduced the resting metabolic rate in diabetic rats; and also lowered plasma triglyceride, total cholesterol and low-density lipoprotein cholesterol. These results suggest that the administration of vitamin C in this model of established diabetes mellitus might be beneficial for the restoration of basal metabolic rate and improvement of lipid profile. This may at least in part reduce the risk of cardiovascular events seen in diabetes mellitus.


Ascorbic acid diabetes mellitus lipid profile metabolic rate vitamin C 

Abbreviations used


Basal metabolic rate


diabetes mellitus


high density lipoprotein


low density lipoprotein


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Copyright information

© Indian Academy of Sciences 2006

Authors and Affiliations

  • D. U. Owu
    • 1
  • A. B. Antai
    • 1
  • K. H. Udofia
    • 1
  • A. O. Obembe
    • 1
  • K. O. Obasi
    • 1
  • M. U. Eteng
    • 2
  1. 1.Department of PhysiologyCollege of Medical Sciences University of CalabarCalabarNigeria
  2. 2.Department of BiochemistryCollege of Medical Sciences University of CalabarCalabarNigeria

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