Journal of Chemical Sciences

, Volume 116, Issue 5, pp 265–270 | Cite as

Synthesis of spiro[indolo-1,5-benzodiazepines] from 3-acetyl coumarins for use as possible antianxiety agents

  • Raviraj A. Kusanur
  • Manjunath Ghate
  • Manohar V. Kulkarni


3-Acetyl coumarins (1) when allowed react with isatin (2) gave corresponding 3-(3′-hydroxy-2′-oxo indolo) acetyl coumarins (3), which on dehydration afforded the correspondingα,β-unsaturated ketones (4). Cyclocondensation of (4) with substitutedo-phenylene diamines resulted in novel 3-coumarinyl spiro[indolo-1,5-benzodiazepines] (5). Structures of all the compounds have been established on the basis of their IR, NMR and mass spectral data and have been screened for their antimicrobial activity and antianxiety activity in mice

Key words

Spirobenzodiazepines distereotopic protons antianxiety activity 


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Copyright information

© Indian Academy of Sciences 2004

Authors and Affiliations

  • Raviraj A. Kusanur
    • 1
  • Manjunath Ghate
    • 2
  • Manohar V. Kulkarni
    • 1
  1. 1.Department of Studies in ChemistryKarnataka UniversityDharwadIndia
  2. 2.Kripanidhi College of PharmacyBangaloreIndia

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