Journal of Chemical Sciences

, Volume 115, Issue 5–6, pp 373–400 | Cite as

Non-protein amino acids in peptide design

  • S. Aravinda
  • N. Shamala
  • Rituparna S. Roy
  • P Balaram

Abstract

An overview of the use of non-protein amino acids in the design of conformationally well-defined peptides, based on work from the author’s laboratory, is discussed. The crystal structures of several designed oligopeptides illustrate the useα-aminoisobutyric acid (Aib) in the construction of helices, D-amino acids in the design of helix termination segments andDPro-Xxx segments for nucleating ofβ-hairpin structures.β- andγ-amino acid residues have been used to expand the range of designed polypeptide structures.

Keywords

Peptide design crystal structures C-H…O hydrogen bond hybrid peptides D-amino acids β-amino acids 

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Copyright information

© Indian Academy of Sciences 2003

Authors and Affiliations

  • S. Aravinda
    • 1
  • N. Shamala
    • 1
  • Rituparna S. Roy
    • 2
  • P Balaram
    • 2
    • 3
  1. 1.Department of PhysicsIndian Institute of ScienceBangaloreIndia
  2. 2.Molecular Biophysics UnitIndian Institute of ScienceBangaloreIndia
  3. 3.Chemical Biology UnitJawaharlal Nehru Centre for Advanced Scientific ResearchBangaloreIndia

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