Journal of Biosciences

, Volume 27, Issue 3, pp 207–218 | Cite as

Carbon — the first frontier of information processing

  • Apoorva Patel
Article

Abstract

Information is often encoded as an aperiodic chain of building blocks. Modern digital computers use bits as the building blocks, but in general the choice of building blocks depends on the nature of the information to be encoded. What are the optimal building blocks to encode structural information? This can be analysed by substituting the operations of addition and multiplication of conventional arithmetic with translation and rotation. It is argued that at the molecular level, the best component for encoding discretized structural information is carbon. Living organisms discovered this billions of years ago, and used carbon as the back-bone for constructing proteins that function according to their structure. Structural analysis of polypeptide chains shows that an efficient and versatile structural language of 20 building blocks is needed to implement all the tasks carried out by proteins. Properties of amino acids indicate that the present triplet genetic code was preceded by a more primitive one, coding for 10 amino acids using two nucleotide bases.

Keywords

Amino acid aminoacyl-tRNA synthetase computation genetic code information lattice models protein structure quantum search tetrahedral geometry 

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References

  1. Agarwala R, Batzoglou S, Dančik V, Decatur S E, Hannenhalli S, Farach M, Muthukrishnan S and Skiena S 1997 Local rules for protein folding on a triangular lattice and generalized hydrophobicity in the HP model;J. Comput. Biol. 4 275–296PubMedGoogle Scholar
  2. Arnez J G and Moras D 1997 Structural and functional considerations of the aminoacylation reaction;Trends Biochem. Sci. 22 211–216PubMedCrossRefGoogle Scholar
  3. Creighton T E (ed.) 1992Protein folding (New York: W H Freeman)Google Scholar
  4. Crick F H C 1966 Codon-anticodon pairing: The wobble hypothesis;J. Mol. Biol. 19 548–555PubMedGoogle Scholar
  5. Crick F H C 1968 The origin of the genetic code;J. Mol. Biol. 38 367–379PubMedCrossRefGoogle Scholar
  6. Eriani G, Delarue M, Poch O, Gangloff J and Moras D 1990 Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs;Nature (London)347 203–206CrossRefGoogle Scholar
  7. Fersht A 1999Structure and mechanism in protein science: A guide to enzyme catalysis and protein folding (New York: W H Freeman)Google Scholar
  8. Grover L 1997 Quantum mechanics helps in searching for a needle in a haystack;Phys. Rev. Lett. 79 325–328 [quant-ph/9706033]CrossRefGoogle Scholar
  9. Hart W E and Istrail S 1997 Lattice and off-lattice side chain models of protein folding: Linear time structure prediction better than 86% of optimal;J. Comput. Biol. 4 241–259PubMedCrossRefGoogle Scholar
  10. Ikehara K 2002 Origins of gene, genetic code, protein and life: Comprehensive view of life systems from a GNC-SNS primitive genetic code hypothesis;J. Biosci. 27 165–186PubMedGoogle Scholar
  11. Kolaskar A S and Ramabrahmam V 1982 Obligatory amino acids in primitive proteins;Biosystems 15 105–109PubMedCrossRefGoogle Scholar
  12. Lehninger A L, Nelson D L and Cox M M1993Principles of biochemistry second edition (USA: Worth Publishers)Google Scholar
  13. Lewin B 2000Genes VII (Oxford: Oxford University Press)Google Scholar
  14. Patel A 2000 Quantum algorithms and the genetic code;Proc. Winter Institute on Foundations of Quantum Theory and Quantum Optics (Calcutta);Pramān.a — J. Phys. 56 367–381 [quant-ph/0002037]Google Scholar
  15. Patel A 2001 Quantum database search can do without sorting;Phys. Rev. A 64 034303 [quant-ph/0012149]CrossRefGoogle Scholar
  16. Ramachandran G N, Ramakrishnan C and Sasisekharan V 1963 Stereochemistry of polypeptide chain configurations;J. Mol. Biol. 7 95–99PubMedGoogle Scholar

Copyright information

© Indian Academy of Sciences 2002

Authors and Affiliations

  • Apoorva Patel
    • 1
  1. 1.Centre for Theoretical Studies and Supercomputer Education and Research CentreIndian Institute of ScienceBangaloreIndia

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