Journal of Biosciences

, 28:637 | Cite as

An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants

  • Vinod Shanker DubeyEmail author
  • Ritu Bhalla
  • Rajesh Luthra


Terpenoids are known to have many important biological and physiological functions. Some of them are also known for their pharmaceutical significance. In the late nineties after the discovery of a novel non-mevalonate (non-MVA) pathway, the whole concept of terpenoid biosynthesis has changed. In higher plants, the conventional acetate-mevalonate (Ac-MVA) pathway operates mainly in the cytoplasm and mitochondria and synthesizes sterols, sesquiterpenes and ubiquinones predominantly. The plastidic non-MVA pathway however synthesizes hemi-, mono-, sesqui- and di-terpenes, along with carotenoids and phytol chain of chlorophyll. In this paper, recent developments on terpenoids biosynthesis are reviewed with respect to the non-MVA pathway.


Acetate-mevalonate DOXP non-MVA pathway plants terpenoids 

Abbreviations used


adenosine triphosphate


cytidine diphosphate






cytidine triphosphate


dimethylal-lyl diphosphate




DOXP synthase


DOXP reductoisomerase


farnesyl diphosphate




geranylgeranyl diphosphate


geranyl diphosphate






3-hydroxy-3-methylglutaryl-CoA reductase


isopentenyl diphosphate


2C-methyl-D-erythritol 2, 4-cyclodiphosphate










thiamin diphosphate


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Copyright information

© Indian Academy of Sciences 2003

Authors and Affiliations

  • Vinod Shanker Dubey
    • 1
    Email author
  • Ritu Bhalla
    • 1
    • 2
  • Rajesh Luthra
    • 1
    • 3
  1. 1.Neurobiotechnology CenterThe Ohio State UniversityColumbusUSA
  2. 2.Plant Microbes Interaction Lab, Department of Biological SciencesNational University of SingaporeSingapore
  3. 3.CSIR ComplexNew DelhiIndia

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