Reloadable antimicrobial coatings based on amphiphilic silicone networks

  • JC TillerEmail author
  • L Hartmann
  • J Scherble


Amphiphilic networks composed of polydimethylsiloxane (PDMS), poly(2-hydroxyethylacrylate) (PHEA), and poly(acrylic acid) (PAA) have been prepared as thin covalently surface-attached coatings via a protecting group strategy. Atomic force microscopy (AFM) images revealed that both the hydrophobic PDMS phase as well as the hydrophilic PHEA and PAA phase, respectively, are present at the surface and show nanophase separation. The coatings were loaded with Rhodamine B (RB) as a model compound for release experiments. The dye is quickly released from the pure PHEA-I-PDMS coatings of all the compositions. In contrast, the release of RB from the PAA-I-PDMS is greatly delayed over weeks. First experiments with PHEA-I-PDMS coatings loaded with the disinfectant cetyltrimethylammonium chloride showed that the antimicrobial activity against the bacteriumStaphylococcus aureus was retained after washing.


Amphiphilic network poly(acrylic acid) polydimethylsiloxane antimicrobial controlled release 

Revêtements antimicrobiens rechargeables et basée sur des réseaux de la silicone amphiphile


Des réseaux amphiphiles et composés de polydiméthylsiloxane (PDMS), de poly(2-hydroxyéthylacrilate) (PHEA), et d’(acide)poly(acrylique) (PAA) ont été traités afin de préparer de minces revêtements qui adhèrent à la surface grâce à un lien covalent par l’intermédiaire d’une stratégie de groupe protecteur. Des images produiles par la microscopie à force atomique (AFM) ont révélé que la phase hydrophobe PDMS aussi bien que la phase hydrophile PHEA et la phase PAA, respectivement, sont présentes à la surface et font preuve d’une séparation nanophasée. Les revêtements étaient chargés de Rhodamine B (RB) en tant que composé modèle pour des expériences de libération. La teinture est vite libérée des revêtements de PHEA-l-PDMS pur dans le cas de toutes les compositions. Par contraste, la libération de RB de la PAA-l-PDMS est retardée pendant des semaines. De premières expériences utilisant des revêtements de PHEA-l-PDMS chargés du désinfectant chlorure de cétyltriméthylammonium ont montré que l’activité antimicrobienne contre la bactérie Staphylococcus aureus était retenue après lavage.

Wiederbeladbare antimikrobielle Beschichtungen auf der Basis von amphiphilen Silikonnetzwerken


Amphiphile Netzwerke, bestehend aus Polydimethylsiloxan (PDMS) und Poly(2-hydroxyethylacrylat) (PHEA) bzw. Poly(acrylsäure) (PAA) wurden in Form dünner, kovalent oberflächengebundener Beschichtungen über eine Schutzgruppentechnik hergestellt. Rasterkraftmikroskopieuntersuchungen ergaben, dass sowohl die hydrophobe (PDMS) als auch die hydrophile (PHEA bzw. PAA) Phase auf der Oberfläche als Nanophasen zu finden sind. Die Beschichtungen wurden mit dem Modelfarbstoff Rhodamine B (RB) beladen. Der Farbstoff wird schnell aus reinen PHEA-I-PDMS Beschichtungen aller Zusammensetzungen abgegeben. Aus PAA-I-PDMS hingegen, erfolgt die RB-Freisetzung über mehrere Wochen. Erste Experimente mit dem Desinfektionsmittel Cetyltrimethylammoniumchlorid zeigten bereits, dass die antimikrobielle Aktivität beladenener PHEA-I-PDMS Beschichtungen gegen das BakteriumStaphylococcus aureus auch nach ausgedehnter Spülzeit erhalten bleibt.


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Copyright information

© OCCA 2005

Authors and Affiliations

  1. 1.Freiburg Materials Research CentreUniversity of FreiburgFreiburgGermany

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