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Medical Oncology

, Volume 24, Issue 2, pp 219–225 | Cite as

CEA levels in serum and BAL in patients suffering from lung cancer

Correlation with individuals presenting benign lung lesions and healthy volunteers
  • Konstantinos Charalabopoulos
  • Agathi Karakosta
  • George Bablekos
  • Christos Golias
  • Alexandros Charalabopoulos
  • Eleni Tsanou
  • Dimitrios Peschos
  • Leonidas Zoganas
  • Anna Batistatou
Original

Abstract

Background

Carcinoembryonic antigen (CEA) is a tumor marker belonging to the immunoglobulin gene superfamily of adhesion molecules. CEA is synthesized by epithelial and tumor cells. In this study, CEA levels in sera and bronchoalveolar lavage fluid (BAL) were measured in patients with malignant lung cancer and benign lung diseases.

Methods

In the present study CEA was measured in serum using IRMA methods and in bronchoalveolar lavage of individuals undergoing fiberoptic bronchoscopy. Fifty patients with lung cancer (G1), 20 patients with benign lung lesions (G2), and a control group consisted of 20 individuals (G3) were enrolled in the study.

Results

We found that serum CEA levels were significantly higher in G1 compared to G2 and G3 (p < 0.01). No significant difference in serum CEA levels was found between smokers and nonsmokers in any of the three groups studied. CEA was significantly higher in G1 BAL (p < 0.05) compared to G2 and G3 BAL. Furthermore, a statistically significant difference was found in CEA levels in BAL between smokers and nonsmokers of G2.

Conclusions

CEA levels in BAL of normal individuals may be influenced by smoking and other factors that affect lung epithelial cell function. Thus, CEA measurement in BAL alone has little value in the diagnosis of malignancy. BAL CEA levels in smokers of G2 are found significantly higher compared with nonsmokers of the same group and healthy individuals. Smokers of G2 have to be followed up carefully for the possibility of lung cancer growth.

Key words

Bronchoalveolar lavage bronchoscopy carcinoembryonic antigen lung cancer 

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References

  1. 1.
    Gold P, Freedman SO. Demonstration at tumor specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques.J Exp Med 1965;121: 439–445.PubMedCrossRefGoogle Scholar
  2. 2.
    Charalabopoulos K, Binolis J, Karkabounas S. Adhesion molecules in carcinogenesis.Exp Oncol 2002;24: 249–257.Google Scholar
  3. 3.
    Charalabopoulos K, Papalimneou V, Charalabopoulos A. Adhesion molecules in lung cancer.Exp Oncol 2003;25: 16–21.Google Scholar
  4. 4.
    Pignatelli M, Durbin H, Bodmer WF. Carcinoembryonic antigen functions as an accessory adhesion molecule mediating colon epithelial cell interactions.Proc Natl Acad Sci USA 1990;87: 1541–1545.PubMedCrossRefGoogle Scholar
  5. 5.
    Jothy S, Yuan SY, Shirota K. Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. In situ hybridization study and implication for a new in vivo functional model.Am J Pathol 1993;143: 250–257.PubMedGoogle Scholar
  6. 6.
    Borong CC, Squires TS, Tong T. Cancer statistics.Cancer 1993;43: 7–20.Google Scholar
  7. 7.
    Doll R, Peto R, Wheatley K, Gray R, Sutherland I. Mortality in relation of smoking: 40 years observations on male British doctors.BMJ 1994;309: 901–911.PubMedGoogle Scholar
  8. 8.
    Reeve JC. Clinical and biological relevance of lung tumor markers.Diagn Oncol 1991;1: 305–315.Google Scholar
  9. 9.
    Niklinski J, Furman M. Clinical tumor markers in lung cancer.Eur J Cancer Prev 1995;4: 129–138.PubMedCrossRefGoogle Scholar
  10. 10.
    Bergman B, Brezicka FT, Engstrom CP, Larson S. Clinical usefulness of serum assays of neuron-specific enolase, carcinoembryonic antigen and CA-50 in the diagnosis of lung cancer.Eur J Cancer 1993;29: 198–202.CrossRefGoogle Scholar
  11. 11.
    Spinazzi A, et al. Evaluation of neuron-specific enolase, tissue polypeptide antigen, and carcinoembryonic antigen as markers for staging and monitoring response to therapy of lung cancer.Cancer Detect Prev 1994;18: 201–220.Google Scholar
  12. 12.
    Buccheri FG, Ferringo D, Sartoris AM, Violante B, Vola F, Curcio A. Tumor markers in brochogenic carcinoma. Superiority of tissue polypeptiode antigene to carcinoembryonic antigen and carbohydrate antigenic determinant 19.9.Cancer 1987;60: 42–50.PubMedCrossRefGoogle Scholar
  13. 13.
    Sawabata N, et al. Serum carcinoembryonic antigen level in surgically resected clinical stage I patients with non-small cell lung cancer.Ann Thorac Surg 2002;74: 174–179.PubMedCrossRefGoogle Scholar
  14. 14.
    Plusa T, Bejm J, Jozefczak E, Swierz J, Drzewiecki Z. Concentration of carcinoembryonic antigen in the serum and bronchoalveolar lavage fluid in patients with lung cancer.Pneumonol Pol 1989;57: 277–282.PubMedGoogle Scholar
  15. 15.
    Okada M, et al. Effect of histologic type and smoking status on interpretation of serum carcinoembryonic antigen value in non-small cell lung carcinoma.Ann Thorac Surg 2004;78: 1004–1009.PubMedCrossRefGoogle Scholar
  16. 16.
    Nonaka M, et al. Pre-and post-operative serum carcinoembryonic antigen in primary lung adenocarcinoma.Ann Thorac Cardiovasc Surg 2004;10: 281–284.PubMedGoogle Scholar
  17. 17.
    Tomita M, Matsuzaki Y, Edagawa M, Shimizu T, Hara M, Onitsuka T: Prognostic significance of preoperative serum carcinoembryonic antigen level in lung adenocarcinoma but not squamous cell carcinoma.Ann Thorac Cardiovasc Surg 2004;10: 76–80.PubMedGoogle Scholar
  18. 18.
    Sugio K, Sugaya M, Hanagiri T, Yasumoto K: Tumor marker in primary lung cancer.J UOEH 2004;26: 473–479.PubMedGoogle Scholar
  19. 19.
    Pardos MC, et al. The concentations of five tumor markers in both BAL fractions in lung cancer patients in relation to cigarette smoking.Tumori 1999;85: 454–457.PubMedGoogle Scholar
  20. 20.
    Dabrowska M, et al. Diagnostic usefulness of selected tumor markers (CA125, CEA, CYFRA 21-1) in bronchoalveolar lavage fluid in patients with non-small cell lung cancer.Pol Arch Med Wewn 2004;111: 659–665.PubMedGoogle Scholar
  21. 21.
    Diego A, Compte L, Sanchis J, Enguidanos MJ, Marco V. Usefulness of carcinoembryonic antigen determination in bronchoalveolar lavage fluid. A comparative study among patients with peripheral lung cancer, pneumonia, and healthy individuals.Chest 1991;100: 1060–1063.PubMedGoogle Scholar
  22. 22.
    The World Health Organisation histological typing of lung tumours. Second edition.Am J Clin Pathol 1982;77: 123–136.Google Scholar
  23. 23.
    Gomm Sot, Keevil BG, Thatcher N. The value of tumor markers in lung cancer.Br J Cancer 1988;18: 797–804.Google Scholar
  24. 24.
    Walop W, Chretien M, Colman NC. The use of biomarkers in the prediction of survival in patients with pulmonary carcinoma.Cancer 1995,65: 2033–2040.CrossRefGoogle Scholar
  25. 25.
    Niklinski J, Chyczewska E, Furman M, Kowal E, Kozlowski M. Value of CEA and SCC-Ag in bronchoalveolar lavage (BAL) and serum of patients with lung carcinoma.Neoplasma 1992;39: 283–285.PubMedGoogle Scholar
  26. 26.
    Goldstein N, Lippmann ML, Goldberg SK, Fein AM, Shapiro B, Leon SA. Usefulness of tumor markers in serum and bronchoalveolar lavage of patients undergoing fiberoptic bronchoscopy.Am Rev Respir Dis 1985;132: 60–64.PubMedGoogle Scholar
  27. 27.
    Pina TC, Zapata IT, Hernandez FC, Lopez JB, Paricio PP, Hernandez PM. Tumour markers in serum, bronchoalveolar lavage and biopsy cytosol in lung carcinoma: what environment lends the optimum diagnostic yield?Clin Chim Acta 2001;305: 27–34.PubMedCrossRefGoogle Scholar
  28. 28.
    Macchia V, et al. Tumor markers and lung cancer: correlation between serum and bronchial secretion levels of CEA, TPA, CanAg CA-50, NSE and ferritin.Int J Biol Markers 1987;2: 151–156.PubMedGoogle Scholar
  29. 29.
    Zaleska J, Pirozynski M, Kwiek S, Sakowicz A, Rowinska-Zakrzewska E. Value of determining the concentration of carcinoembryonic antigen in bronchial lavage for diagnosis of lung cancer.Pneumonol Alergol Pol 1995;63: 286–292.PubMedGoogle Scholar

Copyright information

© Humana Press Inc 2007

Authors and Affiliations

  • Konstantinos Charalabopoulos
    • 1
  • Agathi Karakosta
    • 1
  • George Bablekos
    • 2
  • Christos Golias
    • 1
  • Alexandros Charalabopoulos
    • 3
  • Eleni Tsanou
    • 4
  • Dimitrios Peschos
    • 4
  • Leonidas Zoganas
    • 2
  • Anna Batistatou
    • 4
  1. 1.Department of Physiology, Clinical Unit, Medical FacultyUniversity of IoanninaIoanninaGreece
  2. 2.Department of Thoracic SurgeryRed Cross HospitalAthensGreece
  3. 3.Department of SurgeryPeterborough & Stamford HospitalsCambridgeshireUK
  4. 4.Department of Pathology, Medical FacultyUniversity of IoanninaIoanninaGreece

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