Biological Trace Element Research

, Volume 116, Issue 3, pp 273–278

Evaluation of endemic goiter prevalence in Bulgarian schoolchildren

Results from National strategies for prevention and control of iodine-deficiency disorders
  • Penka Gatseva
  • Stefka Vladeva
  • Mariana Argirova


Iodine deficiency is a major health problem worldwide. The environment of the Balkan countries, including Bulgaria, is distinguished for its low iodine content. In 1994, the strategies for the prevention and control of iodine-deficiency disorders were actualized in Bulgaria and universal salt iodization and supplementation for the risk population groups (schoolchildren, pregnant women) were introduced. The aim of this study was to assess the effectiveness of the iodine prophylaxis in schoolchildren, living in an endemic for goiter area after the introduction of salt iodization in Bulgaria. For this purpose, the goiter prevalence and iodine status in 483 schoolchildren (274 boys and 209 girls) aged between 8 and 15 yr, living in an endemic for goiter area in Bulgaria were evaluated. Despite the normalization of iodine supply, mild iodine deficiency on the basis of goiter prevalence (16.15%) and urinary iodine excretion was found. These data indicate the need for reevaluation of the national strategy for prevention of iodine deficiency.

Index entries

Endemic goiter urinary iodine schoolchildren 


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  1. 1.
    L. Ivanova, Strategies for control of micronutrient deficiencies, inThe Science of Nutrition in Prevention of Human Health, B. Popov, ed., IK Blenda, Sofia, pp. 204–213 (2004).Google Scholar
  2. 2.
    International Council for the Control of Iodine Deficiency Disorders, WHO, UNICEF.Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination. A Guide for Programme Managers, 2nd ed., WHO, Geneva (2001).Google Scholar
  3. 3.
    J. T. Dunn, H. E. Crutchfield, R. Gutekunst, and A. D. Dunn,Methods for Measuring Iodine in Urine, A joint publication of ICCIDD, UNICEF, and WHO, Wageningen, The Netherlands (1993).Google Scholar
  4. 4.
    T. Ohashi, M. Yamaki, C. S. Pandav, M. G. Karmarkar, and M. Irie, Simple microplate method for determination of urinary iodine,Clin. Chem. 46, 529–536 (2000).PubMedGoogle Scholar
  5. 5.
    D. Gnat, A. D. Dunn, S. Chaker, F. Delange, F. Vertongen, and J. T. Dunn, Fast colorimetric method for measuring urinary iodine,Clin. Chem. 49, 186–188 (2003).PubMedCrossRefGoogle Scholar
  6. 6.
    M. Korpal-Szczyrska, B. Dorant, H. Kaminska, L. Bitel, D. Birkholz, and W. Kosiak, Effect of three years obligatory iodine prophylaxis on the incidence of goiter in school children from the seaside region of Poland.Pol. Merkuriusz. Lek. 16, 41–43 (2004).Google Scholar
  7. 7.
    F. Golkowski, B. Huszno, M. Trofimiuk, et al., Prevalence of goiter in schoolchildren: a study on the influence of adequate iodine prophylaxis in Poland,J. Endocrinol. Invest. 26,(Suppl. 2), 11–15 (2003).PubMedGoogle Scholar
  8. 8.
    H. Volzke, J. Ludemann, D. M. Robinson, et al., The prevalence of undiagnosed thyroid disorders in a previously iodine-deficient area,Thyroid 13, 803–810 (2003).PubMedCrossRefGoogle Scholar
  9. 9.
    F. Delange, H. Burgi, Z. P. Chen, and J. T. Dunn, World status of monitoring iodine deficiency disorders control programs,Thyroid 12, 915–924 (2002).PubMedCrossRefGoogle Scholar
  10. 10.
    U. Kapil, V. Sethi, G. Goindi, P. Pathak, and P. Singh, Elimination of iodine deficiency disorders in Delhi,Indian J. Pediatr. 71, 211–212 (2004).PubMedCrossRefGoogle Scholar
  11. 11.
    C. Als, M. Haldimann, C. Minder, and H. Gerber, Pilot study of urinary iodine concentration and of biochemical thyroid parameters before and after cautious public health intervention on salt iodide content: the Swiss longitudinal 1996–2000 iodine study,Eur. J. Clin. Nutr. 58, 1201–1210 (2004).PubMedCrossRefGoogle Scholar
  12. 12.
    J. Rendl, N. Juhran, and C. Reiners, Thyroid volumes and urinary iodine in German school children,Exp. Clin. Endocrinol. Diabetes 109, 8–12 (2001).PubMedCrossRefGoogle Scholar
  13. 13.
    R. Hampel, A. Gordalla, H. Zollner, D. Klinke, and M. Demuth, Continuous rise of urinary iodine excretion and drop in thyroid gland size among adolescents in Mecklenburg-West-Pomerania from 1993 to 1997,Exp. Clin. Endocrinol. Diabetes 108, 197–201 (2000).PubMedCrossRefGoogle Scholar
  14. 14.
    H. Burgi, L. Portmann, J. Podoba, F. Vertongen, and M. Srbecky, Thyroid volumes and urinary iodine in Swiss school children, 17 years after improved prophylaxis of iodine deficiency,Eur. J. Endocrinol. 140, 104–106 (1999).PubMedCrossRefGoogle Scholar
  15. 15.
    M. V. Veldanova, The role of some goitrogenous environmental factors in the endemic goitre genesis,Trace Elements Med. (Russian) 1, 17–25 (2000).Google Scholar

Copyright information

© Humana Press Inc 2007

Authors and Affiliations

  • Penka Gatseva
    • 1
  • Stefka Vladeva
    • 2
  • Mariana Argirova
    • 3
  1. 1.Deptartment of Hygiene and EcomedicineMedical UniversityPlovdivBulgaria
  2. 2.Clinic of EndocrinologyMedical UniversityPlovdivBulgaria
  3. 3.Deptement of Chemistry and BiochemistryMedical UniversityPlovdivBulgaria

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