Alternative splicing of interleukin-6 mRNA in mice

  • O. P. Yatsenko
  • M. L. Filipenko
  • E. A. Khrapov
  • E. N. Voronina
  • S. V. Sennikov
  • V. A. Kozlov
Immunology And Microbiology
Received:

Abstract

Expression of mRNA for interleukin-6, interleukin-6Δ3, and interleukin-6Δ5 was detected in placental tissue (second and third trimesters of pregnancy) and spleen of mice immunized with sheep erythrocytes in high dose. We hypothesize that translation of mRNA yields proteins capable of binding to individual subunits of the interleukin-6 receptor and possessing effector functions.

Key Words

interleukin-6 alternative splicing 
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Copyright information

© Springer Science + Business Media, Inc. 2004

Authors and Affiliations

  • O. P. Yatsenko
    • 1
  • M. L. Filipenko
    • 1
    • 2
  • E. A. Khrapov
    • 1
    • 2
  • E. N. Voronina
    • 1
    • 2
  • S. V. Sennikov
    • 1
  • V. A. Kozlov
    • 1
  1. 1.Laboratory for Regulation of Immunopoiesis, Institute of Clinical ImmunologySiberian Division of the Russian Academy of Medical SciencesUSSR
  2. 2.Institute of Bioorganic ChemistrySiberian Division of the Russian Academy of SciencesNovosibirsk

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