Cerebroprotective effect of combined treatment with pyrazidol and bemitil in craniocerebral trauma
Monotherapy of consequences of craniocerebral trauma with pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemitil in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemitil was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemitil had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.
Key Wordscraniocerebral trauma bemitil pyrazidol behavior metabolism
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- 2.E. E. Dubinina, L. A. Sal’nikova, and L. F. Efimova,Lab. Delo, No. 10, 30–33 (1983).Google Scholar
- 3.I. V. Zarubina,Hypoxia Med. J.,9, Nos. 1–2, 2–9 (2001).Google Scholar
- 5.I. V. Zarubina and O. P. Mironova,Byull. Eksp. Biol. Med.,133, No. 2, 165–167 (2002).Google Scholar
- 6.Methods for Biochemical Assays (Lipid and Energy Metabolism), Ed. M. I. Prokhorov [in Russian], Leningrad (1982).Google Scholar
- 7.L. L. Pragina, N. A. Tushmalova, A. N. Inozemtseva,et al., Eksper. Klin. Farmakol.,62, No. 4, 9–10 (1999).Google Scholar
- 8.M. Sh. Promyslov,Metabolism in the Brain and Its Regulation during Craniocerebral Trauma [in Russian], Moscow (1984).Google Scholar
- 9.Modern Biochemical Methods, Ed. V. N. Orekhovich [in Russian], Moscow (1977).Google Scholar
- 10.M. A. Sherman and A. A. Shutov,Zh. Nevrol. Psikhiatr.,103, No. 1, 17–20 (2003).Google Scholar
- 11.R. M. Frieboes, U. Muller, H. Mirck,et al., J. Neuropsychiat. Clin. Neurosci.,11, No. 3, 354–360 (1999).Google Scholar