Advertisement

Cerebroprotective effect of combined treatment with pyrazidol and bemitil in craniocerebral trauma

  • I. V. Zarubina
  • N. A. Kuritsyna
  • P. D. Shabanov
Pharmacology And Toxicology

Abstract

Monotherapy of consequences of craniocerebral trauma with pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemitil in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemitil was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemitil had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.

Key Words

craniocerebral trauma bemitil pyrazidol behavior metabolism 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Yu. A. Aleksandrovskii, Yu. G. Bobkov, G. G. Neznamov,et al., Zh. Nevropatol. Psikhiatr.,88, No. 3, 109–115 (1988).PubMedGoogle Scholar
  2. 2.
    E. E. Dubinina, L. A. Sal’nikova, and L. F. Efimova,Lab. Delo, No. 10, 30–33 (1983).Google Scholar
  3. 3.
    I. V. Zarubina,Hypoxia Med. J.,9, Nos. 1–2, 2–9 (2001).Google Scholar
  4. 4.
    I. V. Zarubina and B. I. Krivoruchko,Ukr. Biokhim. Zh.,54, No. 4, 437–439 (1982).PubMedGoogle Scholar
  5. 5.
    I. V. Zarubina and O. P. Mironova,Byull. Eksp. Biol. Med.,133, No. 2, 165–167 (2002).Google Scholar
  6. 6.
    Methods for Biochemical Assays (Lipid and Energy Metabolism), Ed. M. I. Prokhorov [in Russian], Leningrad (1982).Google Scholar
  7. 7.
    L. L. Pragina, N. A. Tushmalova, A. N. Inozemtseva,et al., Eksper. Klin. Farmakol.,62, No. 4, 9–10 (1999).Google Scholar
  8. 8.
    M. Sh. Promyslov,Metabolism in the Brain and Its Regulation during Craniocerebral Trauma [in Russian], Moscow (1984).Google Scholar
  9. 9.
    Modern Biochemical Methods, Ed. V. N. Orekhovich [in Russian], Moscow (1977).Google Scholar
  10. 10.
    M. A. Sherman and A. A. Shutov,Zh. Nevrol. Psikhiatr.,103, No. 1, 17–20 (2003).Google Scholar
  11. 11.
    R. M. Frieboes, U. Muller, H. Mirck,et al., J. Neuropsychiat. Clin. Neurosci.,11, No. 3, 354–360 (1999).Google Scholar
  12. 12.
    S. Pellow and S. E. Fele,Pharmacol. Biochem. Behav.,24, No. 3, 525–529 (1986).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science + Business Media, Inc. 2004

Authors and Affiliations

  • I. V. Zarubina
    • 1
  • N. A. Kuritsyna
    • 1
  • P. D. Shabanov
    • 1
  1. 1.Department of PharmacologyS. M. Kirov Military Medical Academy, Russian Ministry of DefenseSt. Petersburg

Personalised recommendations