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Bulletin of Experimental Biology and Medicine

, Volume 138, Issue 8, pp 165–167 | Cite as

Study of mutagenic activity of dioxidine by the polyorgan micronuclear method

  • L. P. Sycheva
  • M. A. Kovalenko
  • S. M. Sheremet’eva
  • A. D. Durnev
  • V. S. Zhurkov
Pharmacology And Toxicology

Abstract

Antibacterial preparation dioxidine administered four times in doses of 10, 100, and 300 mg/kg increased the incidence of micronucleated cells in the bone marrow, lungs, and large intestine of mice. Bone marrow cells were most sensitive, while cells of the lungs and large intestine exhibited lower sensitivity to the cytogenetic effect of dioxidine.

Key Words

dioxidine mutagenic effect polyorgan micronuclear test lungs large intestine 

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Copyright information

© Springer Science+Business Media, Inc 2004

Authors and Affiliations

  • L. P. Sycheva
    • 1
  • M. A. Kovalenko
    • 1
  • S. M. Sheremet’eva
    • 1
  • A. D. Durnev
    • 1
    • 2
  • V. S. Zhurkov
    • 1
  1. 1.Laboratory of Genetic Monitoring, A. N. Sysin Institute of Human Ecology and Environmental HygieneRussian Academy of Medical SciencesUSSR
  2. 2.Laboratory of Mutagenesis, Institute of PharmacologyRussian Academy of Medical SciencesMoscow

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