Biological basis of the stress response

Address upon accepting the Hans Selye Award from the American institute of stress in Montreux, Switzerland, February 1991
  • James P. Henry
Special Section


Chronic, as well as acute emotional arousal, is a consequence of various types of social interaction, i.e., those between mother and infant and between controlling dominant and less effective subordinate. The neurohumoral accompaniments of this social stress include the sympathetic adrenal medullary and hypothalamic pituitary adrenal responses. A common ensuing pathophysiological state involves a chronic increase of blood pressure. Although Selye’s General Adaptation Syndrome presupposed the same response to a variety of stimuli; recent work shows that specific perceptions of control result in different patterns of neuroendocrine activation. A challenge perceived as easy to handle will elicit an active coping response and release of the neurosympathetic system’s norepinephrine. Testosterone will rise as the subject savors success. With increasing anxiety this active coping shifts to a more passive mode and the behavior becomes less assured as the animal loses control. The norepinephrine/epinephrine ratio decreases as epinephrine, prolactin, renin and fatty acids rise. As the outcome becomes still less certain and distress grows, adrenocorticotropic hormone and cortisol levels arise. Thus, the effort required on the one hand and the degree of frustration conflict and uncertainty on the other, determine the ratio of catecholamines to corticoids. With severe emotional trauma, brain dysfunction may occur. These effects can be lasting, and corticoids paradoxically return to normal as the behavior changes to that of post-traumatic stress disorder. Repression and denial set in and the organism responds with decreased concern of impaired attachment and increased irritability.


Oxytocin Corticotrophin Release Hormone Plasma Corticosterone Alexithymia Adrenal Weight 
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  1. Adams, N., & Blizard, D.A. (1987). Defeat and cardiovascular responses.The Psychological Record, 37, 349–368.Google Scholar
  2. American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed. rev.). Washington, D.C.: American Psychiatric Association Press.Google Scholar
  3. Arnold, L.E. (1990).Childhood stress. New York: Wiley.Google Scholar
  4. Benus, I. (1988). Aggression and coping: Differences in behavioral strategies between aggressive and non-aggressive male mice. Unpublished doctoral dissertation, Gronigen Holland.Google Scholar
  5. Bjorntorp, P. (1987). The association between obesity, adipose tissue distribution and disease.Acta Medica Scandinavica, 723, 121–134.Google Scholar
  6. Buck, R. (1988). Central nervous system mechanisms of motivation and emotion. InHuman motivation and emotion. New York: Wiley.Google Scholar
  7. de Boer, S.F. (1990).Dynamics of stress hormones in the rat. Modification by psychological factors and anxiolytic drugs. The Netherlands: University of Utrecht. Department of Psychopharmacology/Physiology.Google Scholar
  8. de Boer, S.F., De Beun, R., Slangen, J.L., & Van der Gugten, J. (1990). Dynamics of plasma catecholamine and corticosterone concentrations during reinforced and extinguished behavior in rats.Physiology and Behavior, 47, 691–698.PubMedCrossRefGoogle Scholar
  9. Dunn, A.J., & Kramercy, N.R. (1984). Neurochemical responses in stress. Relationships between the hypothalamic-pituitary-adrenal and catecholamine systems. In L.L., Iverson, D.S. Iverson, & S.H. Snyder (Eds),Handbook of psychopharmacology Vol. 18, (pp 455–515). New York: Plenum Press.Google Scholar
  10. Engel, G.L., & Schmale, A.H. (1972). Conservation-withdrawal: A primary regulatory process for organismic homeostasis.Physiology, Emotion and Psychosomatic Illness, Ciba Foundation Symposium, 8, 57–76.Google Scholar
  11. Ferris, C.F., Foote, K.B., Meltser, H.M., Plenby, M.G., Smith, K.L., & Insel, T. (in press). Oxytocin in the amygdala increases maternal aggression. In C.A., Pedersen, J.D., Caldwell, G., Jirikowski, T.R., Insel (Eds),Oxytocin in Maternal, sexual and social Behaviors. New York: Annals of the New York Academy of Sciences.Google Scholar
  12. Fokkema, D.S., & Koolhaas, J.M. (1985). Acute and conditioned blood pressure changes in relation to social and psychosocial stimuli in rats.Physiology and Behavior, 34, 33–38.PubMedCrossRefGoogle Scholar
  13. Folkow, B. (1985). Stress and blood pressure in adrenergic blood pressure regulation. Current Clinical Practice Series. Birkenhager, W.H., Folkow, B., Struyker Boucher, H.A.J. Amsterdam Exerpta Medica, pp 87–93.Google Scholar
  14. Gold, P.W., Goodwin, F.K., & Chrousos, G.P. (1988). Clinical and biochemical manifestations of depression: Relation to the neurobiology of stress.New England Journal of Medicine, 319, 413–420.PubMedCrossRefGoogle Scholar
  15. Goldberg, J., True, R., & Henderson, J. (1990). A twin study of the effects of the Vietnam war on posttraumatic stress disorder.JAMA, 263, 1227–1232.PubMedCrossRefGoogle Scholar
  16. Henry, J.P., & Stephens, P. (1981). Psychosocial stress induces tubulointerstitial nephritis unrelated to hypertension in CBA mice.Clinical and Experimental Pharmacology and Physiology, 8, 483–487.PubMedCrossRefGoogle Scholar
  17. Henry, J.P., Stephens, P.M., Axelrod, J. & Mueller, J.A. (1971). Effect of psychosocial stimulation on the enzymes involved in the biosynthesis and metabolism of noradrenaline and adrenaline.Psychosomatic Medicine, 33, 227–237.PubMedGoogle Scholar
  18. Henry, J.P., & Stephens, P.M. (1977).Stress health and the social environment: A sociobiological approach to medicine. New York: Springer Verlag.Google Scholar
  19. Henry, J.P., & Meehan, J.P. (1981). Psychosocial stimuli, physiological specificity and cardiovascular disease. In H. Weiner, H.A. Hofer, & A.J., Stunkard, (Eds.),Brain behavior and bodily disease (pp. 305–333). New York: Raven.Google Scholar
  20. Henry, J.P., Stephens, P.M., & Ely, D.L. (1986). Psychosocial hypertension and the defense defeat reactions.Journal of Hypertension, 4, 687–697.PubMedCrossRefGoogle Scholar
  21. Henry, J.P., Haviland, M.G., Cummings, M.A., Anderson, D., Nelson, J.C., MacMurray, J.P., McGhee, W.H., & Hubbard, R.W. Neuroendocrine aspects of alexithymia among alcohol-dependent men. Submitted for publication.Google Scholar
  22. Henry, J.P., & Meehan, W.P. (in press). Psychoemotional hypertension in animals. In Johnson, E.H., & Julius S. (Eds).Personality, elevated blood pressure and essential hypertension. New York: Hemisphere Press.Google Scholar
  23. Holst, D.V. (1986). Vegatative and somatic components of tree shrew’s behavior.Journal of the Autonomic Nervous System, (suppl.), 657–670.Google Scholar
  24. Julius, S. (1988). Interaction between renin and the autonomic nervous system in hypertension.American Heart Journal, 116, 181–185.CrossRefGoogle Scholar
  25. Koolhaas, J., & Bohus, B. (1989). Social control in relation to neuroendocrine and immunological responses. In A. Steptoe, & A. Appels (Eds),Stress personal control and health. New York: Wiley.Google Scholar
  26. Lundberg, U., & Frankenhaeuser, M. (1980). Pituitary-adrenal and sympathetic-adrenal correlates of distress and effort.Journal of Psychosomatic Research, 24, 125–130.PubMedCrossRefGoogle Scholar
  27. MacLean, P.D. (1990).The triune brain in evolution: Role in paleocerebral functions. New York: Plenum.Google Scholar
  28. Mason, J.W., Maher, J.T., Hartley, L.H., Mougey, E.H., Perlow, M.J., & Jones, L.G. (1976). Selectivity of corticosteroid and catecholamine responses to various natural stimuli. In G. Serban (Ed.),Psychopathology of human adaptation, (pp. 147–171). New York: Plenum.Google Scholar
  29. Mason, J.W., Giller, E.L., Kosten, T.R., & Harkness, L. (1988). Elevation of urinary norepinephrine/cortisol ratio in posttraumatic stress disorder.Journal of Nervous and Mental Disease, 176, 498–502.PubMedCrossRefGoogle Scholar
  30. Mason, J.W., Giller, E.L., Kosten, T.R., & Yehuda, R. (1990). Psychoendocrine approaches to the diagnosis and pathogenesis of PTSD. In E.L. Giller (Ed.),Biologic assessment and treatment of post-traumatic stress disorder. Washington, D.C.: American Psychiatric Press.Google Scholar
  31. Nixon, P.G.F. (1982). Stress and the cardiovascular system.The Practitioner, 226, 1589–1598.PubMedGoogle Scholar
  32. Pedersen, C.A., Caldwell, J.D., Jirikowski, G., & Insel, T. (in press).Oxytocin in maternal, sexual and social behaviors. New York: Annals of the New York Academy of Sciences.Google Scholar
  33. Rebuffe-Scrive, M., Walsh, U.A., McEwin, B., & Rodin, J. (1992). The effect of chronic stress on regional distribution of fat. Submitted for publication.Google Scholar
  34. Sapolsky, R.M. (1988). Individual differences and the stress response. In Mechanisms of physical and emotional stress. Chrousos, G.P., Loriaux, L. and Gold, P.W. (Eds).Advances in Experimental Medicine and Biology 243: 399–412.Google Scholar
  35. Selye, H. (1936). A syndrome produced by diverse noxious agents.Nature, 138, 32–34.CrossRefGoogle Scholar
  36. Selye, H. (1974).Stress without distress. Philadelphia, Lippincott.Google Scholar
  37. Seligman, M.E.P. (1991).Learned optimism. New York: Knopf.Google Scholar
  38. Smelik, P.G. (1985). Stress and hormones.Organorama, 22, 16–18.Google Scholar
  39. Stock, G., Schlor, K.H., Heidt, H., & Buss, J. (1978). Psychomotor behavior and cardiovascular patterns during stimulation of the amygdala.Pfleuger’s Archives, 376, 177–184.CrossRefGoogle Scholar
  40. Stock, G., Passfall, J., Schultz, B.G., Kluge, W., Lambertz, M., & Langhorst, P. (1988). Suppression of baroreceptor function by the amygdaloid complex at the level of the nucleus of the solitary tract.Journal of Hypertension, 6(supp 4), S738.Google Scholar
  41. Suh, B.Y., Liu, J.H., Rasmussen, D.D., Gibbs, D.M., Steinberg, J., & Yen, S.C. (1986). The role of oxytocin in the modulation of ACTH release in women.Neuroendocrinology, 44, 309–313.PubMedCrossRefGoogle Scholar
  42. TenHouten, W.D., Hoppe, K.D., Bogen, J.E., & Walter, D.O. (1986). Alexithymia: An experimental study of cerebral commissurotomy patients and normal control subjects.American Journal of Psychiatry, 143, 312–316.PubMedGoogle Scholar
  43. Vander, A.J., Henry, J.P., Stephens, P.M., Kay, L.L., & Mouw, D.R. (1978). Plasma renin activity in psychosocial hypertension of CBA mice.Circulation Research, 42, 496–502.PubMedGoogle Scholar
  44. Van der Kolk, B.A. (1987).Psychological trauma. Washington, D.C.: American Psychiatric Press.Google Scholar
  45. Wolff, C.T., Hofer, M., & Mason, J.W. (1964). Relationship between psychological defenses and mean urinary 17-Hydroxycorticosteroid excretion rates 11 Methodologic and theoretical considerations.Psychosomatic Medicine, 26, 592–609.PubMedGoogle Scholar
  46. Zeitlin, S.B., Lane, R.D., O’Leary, D.S., & Schrift, M.J. (1989). Interhemispheric transfer deficit and alexithymia.American Journal of Psychiatry, 146, 312–316.Google Scholar

Copyright information

© Springer 1992

Authors and Affiliations

  • James P. Henry
    • 1
  1. 1.Hypertension CenterDrew Medical SchoolLos Angeles

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