Tic douloureux, Parkinson’s disease and the herpes connection

  • James S. Howard


Several cases encountered in psychiatric practice are described in which herpetic involvement of the trigeminal nerve appeared to be crucial to the pathophysiology of the patients’s illness. A brief history of herpes is discussed in terms of the anatomy and physiology of the trigeminal nerve. Particular attention is given to the effects of intraneuronal herpes on gasserian ganglion and spinal nuclei discharge threshoolds, as well as viral pathways directly impacting the substantia nigra. Evidence characterizing Parkinson’s disease as one of several important manifestations of CNS herpes is covered.


Herpes Simplex Type Herpes Zoster Acyclovir Trigeminal Nerve Parkinsonian Symptom 
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  1. Brain, Lord and Walton, J.N. (1969).Brain’s Diseases of the Nervous System, 7th edition. London: Oxford University Press.Google Scholar
  2. Charcot, J.M. (1877).Lecons sur le maladies du Systeme Nerveux. Paris: V.A. Delahaye et Cie.Google Scholar
  3. Chiodo, L.A. (1980). Sensory Stimuli Alters the Discharge Rate of Dopamine (DA) Neurons: Evidence for Two Functional Types of DA Cells in the Substantia Nigra.Brain Research 189: 544–549.PubMedCrossRefGoogle Scholar
  4. Critchley, M. (Ed.). (1955).James Parkinson (1755–1824). London: Macmillan, pp. 145–218.Google Scholar
  5. During, M.J. (1994). Long-term Behavioral Recovery in Parkinsonian Rats by an HSV Vector Expressing Tyrosine Hydroxylase.Science 299:1399–1403.CrossRefGoogle Scholar
  6. Freese, A. (1991). Infection of Cultured Striatal Neurons with a Defective HSV-1 Vector. Implications for Gene Theraphy.Nucleic Acids Research 1(25): 7219–7223.CrossRefGoogle Scholar
  7. Fromm, G.H. (1984). Role of Inhibitory Mechanisms in Trigeminal Neuralgia.Neurology 3: 683–687.Google Scholar
  8. Gebhardt, B.M. (1995). Propranolol Suppression of Reactivation of the Herpes Virus.Antiviral Research 27 (3): 255–261.PubMedCrossRefGoogle Scholar
  9. Guter, W. (1924). Das Herpesvirus Seine atiologische und Klinische Beteutung.Munchener Medizinische Wochenschrift 71: 1058.Google Scholar
  10. Harting, J.K. (1991). Spatial Relationships of Axons Arising from the Substantia Nigra, Spinal Trigeminal Nucleus, and Pedunculopontine Tegmental Nucleus within the Intermediate Gray of the Cat Superior Colliculus.The Journal of Comparative Neurology 305: 543–558.PubMedCrossRefGoogle Scholar
  11. Herishanu, Y. (1973). An Acute Encephalitic Parkinsonian Syndrome: Case Report and Review of the Recent Literature.European Neurology 10: 117–124.PubMedCrossRefGoogle Scholar
  12. Howard, J.S. (1996). Herpes Encephalitis, Schizophrenia and the Crossroads of Psychiatry.Integrative Behavioral and Physiological Science 31 (3): 218–222.Google Scholar
  13. Huston, J.P. (1990). The Basal Ganglia Orofacial System: Studies on Neuro-behavioral Plasticity and Sensorymotor Tuning.Neuroscience & Behavioral Reviews 14: 433–446.CrossRefGoogle Scholar
  14. Kugelberg, H. and Lindblum, N. (1959). The Mechanism of Pain in Trigeminal Neuralgia.Journal of Neurology, Neurosurgery and Psychiatry 22: 36–45.CrossRefGoogle Scholar
  15. Levaditi, C. (1929). Etiology of Epidemic Encephalitis. Its Relation to Herpes, Epidemic Poliomyelitis, and Post-vaccinal Encephalopathy.Archives of Neurology and Psychiatry 22: 767–803.Google Scholar
  16. Macdonald, C. (1955).James Parkinson (1755–1824) London: Macmillan.Google Scholar
  17. Netter, F.H. (1986).The Ciba Collection of Medical Illustrations. Vol. 1, West Caldwell, N.J.: CibaGeigy.Google Scholar
  18. Paivarinta, J. (1993). Dopaminergic Neurotransmission in Chronic Herpes Simples Virus Brain Infection in Rabbits.Journal of Neurological Transmission 53: 125–133.Google Scholar
  19. Rail, D. (1981): Post-encephalitic Parkinson, Current Experience.Journal of Neurology, Neurosurgery and Psychiatry, 44: 670–676.CrossRefGoogle Scholar
  20. Sanders, V.J. (1996). Herpes Simplex Virus in Postmortem Multiple Sclerosis Brain Tissue.Archives of Neurology 53: 125–133.PubMedGoogle Scholar
  21. Schwarting, R. K. W. (1991). Trigeminal-basal Ganglia Interaction: Control of Sensory-motor Gating and Positive Reinforcement.Brain Research Bulletin 26: 293–300.PubMedCrossRefGoogle Scholar
  22. Solbrig, M.V. (1993). Acute Parkinsonism in Suspected Herpes Simplex Encephalitis Movement Disorder.Movement Disorders 8(2):233–234.PubMedCrossRefGoogle Scholar
  23. Vinken, P.J. (1968).Handbook of Clinical Neurology. New York: John Wiley and Sons.Google Scholar
  24. Von Economo, C. (1917). Encephalitis Lethargica.Wein. Klin. Wschr. 30: 581–585.Google Scholar
  25. Williams, P.L. (1980).Gray’s Anatomy, 36th edition. Vienna: Churchill Livingstone.Google Scholar
  26. Yahr, M.D. (1987). Deprenyl and Parkinsonism.Journal of Neurological Transmission 25 (Suppl.): 5–12.Google Scholar
  27. Zemanick, M.C. (1991). Direction of Transneuronal Transport of Herpes Simplex Virus 1 in the Primary Motor System is Strain-dependent.Proceedings of the National Academy of Science, USA 88: 8048–8051.CrossRefGoogle Scholar

Copyright information

© Springer 1996

Authors and Affiliations

  • James S. Howard
    • 1
  1. 1.Mental Health UnitSouthland HospitalInvercargillNew Zealand

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