Pharmacological effects on lateralized behavior
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Sixteen student volunteers were administered a placebo and 50 mg. of chlorpromazine in tablet form, on separate occasions, two hours before testing. The three tests measured dichotic listening performance, lateral eye movements while answering questions about spatial location and verbal meaning, and lateralized facial expression while relating pleasant and unpleasant life incidents. Results showed that chlorpromazine increased the number of trials showing an ear advantage in dichotic listening. Chlorpromazine reduced lateral and increased vertical eye movements in response to the questions about spatial location and verbal meaning. Under the placebo both negative and positive emotions were expressed more in the left face. Although chlorpromazine did not affect this lateralization of negative emotions, the expression of positive emotions occurred equally often on the two sides of the face under chlorpromazine. Results may be related to an effect of chlorpromazine on the asymmetrical dopamine pathways of the brain. It is suggested that the findings may be related to a left hemisphere deficit in schizophrenia.
KeywordsSchizophrenia Facial Expression Positive Emotion Chlorpromazine Dichotic Listening
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- Bryden, M.P. (1982).Laterality: Functional Asymmetry in the intact brain. New York: Academic Press.Google Scholar
- Caudrey, D.J., & Kirk, K. (1979). The perception of speech in schizophrenic and affective disorders. In J. Gruzelier & P. Flor-Henry (Eds.),Hemisphere asymmetry of function in psychopathology. New York: North-Holland.Google Scholar
- Glick, S.D., Jerussi, T.P., & Zimmerberg, B. (1976), Behavioural and neuropharmacological correlates of nigrostriatal asymmetry in rats. In S. Harmar, K.W. Duty, L. Goldstein, J. Jayna, & G. Krathemer,Lateralization in the nervous system, London: Academic Press.Google Scholar
- Green, P., Hallett, S., & Hunter, M. (1983). Abnormal interhemispheric integration and hemispheric specialization in schizophrenia and high-risk children. In P. Flor-Henry & J. Gruzelier (Eds.),Laterality and psychopathology. Amsterdam: North-Holland.Google Scholar
- Iversen, S.D., & Iversen, L.L. (1981).Behavioural pharmacology. Oxford: Oxford University Press.Google Scholar
- McGuinness, D., & Pribram, K. (1980). The neuropsychology of attention: Emotional and motivational controls. In M.C. Wittrock (Ed.),The brain and psychology. New York: Academic Press.Google Scholar
- Wagner, H.N., Burns, D.H., Danuals, R.F., Wong, D.F., Langstrom, B., Duelfer, T., Frost, J.J., Ravert, H.T., Links, J.M., Rosenbloom, S.B., Lucas, S.E., Kramer, A.V., & Kuhler, M.J. (1983). Imaging dopamine receptors in the human brain by position tomography.Science, 221, 1264–1266.CrossRefPubMedGoogle Scholar