Biotherapy

, Volume 10, Issue 4, pp 299–308 | Cite as

Hematopoietic growth factors in autologous transplantation

  • Gian Carlo Avanzi
  • Margherita Gallicchio
  • Giuseppe Saglio
Article

Abstract

Hematopoietic growth factors (HGFs) sustain the survival, proliferation and differentiation of hematopoietic stem cells and some functions of mature blood cells. In man several HGFs have been characterised and cloned so far, and this has allowed investigators to confer the rationale for the clinical application of these molecules in hematology and oncology. In particular G-CSF and GM-CSF are currently utilised to abrogate the hematological toxicity of chemotherapy for standard and dose-intensified therapy, neutropenia following bone marrow and peripheral blood stem cell transplantation. Moreover there has recently been great interest in the ex vivo expansion of hematopoietic stem and progenitor cells for a variety of applications, such as in vitro tumor cell purging or for reducing the volume of blood processed by the leukapheresis. Several combinations of HGFs have been described to sustain the ex vivo survival and proliferation of these cells disclosing new opportunities in the field of stem cells transplants.

Key words

hematopoietic growth factors bone marrow transplantation peripheral blood progenitor cells transplantation granulocyte colony-stimulating factor granulocyte-monocyte colony-stimulating factor hematopoietic stem cells 

Abbreviations

HGFs

Hematopoietic Growth Factors

G-CSF

Granulocyte Colony-Stimulating Factor

GM-CSF

Granulocyte Monocyte Colony-Stimulating Factor

EPO

Erythropoietin

M-CSF

Monocyte Colony-Stimulating Factor

IL-5

Interleukin-5

IL-3

Interleukin-3

SCF

Stem Cell Factor

KR

c-kit Receptor

BFU-MK

Burst Forming Unit Megakaryocyte

HPP-CFC

High Proliferative Potential Colony-Forming Cell

LTC-IC

Long-Term Culture-Initiating Cell

FL

Flt3-ligand

CFU-GM

Granulocyte-Monocyte Colony-Forming Unit

CFU-M

Monocyte Colony-Forming Unit

IL-6

Interleukin-6

IL-11

Interleukin-11

CFU-GEMM

Granulocyte-Erythrocyte-Monocyte-Megakaryocyte Colony-Forming Unit

CFU-MK

Megakarocyte Colony-Forming Unit

CFU-Eos

Eosinophil Colony-Forming Unit

BFU-E

Erythroid Burst-Forming Unit

CFU-G

Granulocyte Colony-Forming Unit

ADCC

Antibody-Dependent Cell-mediated Cytotoxicity

TNF

Tumor Necrosis Factor

TPO

Thrombopoietin

CFU-mix

Multilineage Colony-Forming Unit

CAMs

Cell Adhesion Molecules

PBPC

Peripheral Blood Progenitor Cells

PB

Periferal Blood

LTBMCs

Long Term Bone Marrow Cells

CFCs

Colony-Forming Cells

NGF-β

Nerve Growth Factor Beta

CFU-C

Colony-Forming Unit-Cell

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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Gian Carlo Avanzi
    • 1
  • Margherita Gallicchio
    • 1
  • Giuseppe Saglio
    • 2
  1. 1.Medical Clinic, Dept. of Medical ScienceUniversity of TurinNovaraItaly
  2. 2.Medical Clinic, Dept. of Biomedical Science and Human OncologyUniversity of TurinNovaraItaly

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