Biotherapy

, Volume 10, Issue 1, pp 7–14

Interferon antibodies in patients with infectious diseases

Anti-interferon antibodies
  • G. Antonelli
  • E. Simeoni
  • M. Currenti
  • F. De Pisa
  • V. Colizzi
  • M. Pistello
  • F. Dianzani
Article

DOI: 10.1007/BF02678212

Cite this article as:
Antonelli, G., Simeoni, E., Currenti, M. et al. Biotherapy (1997) 10: 7. doi:10.1007/BF02678212

Abstract

Interferons (IFNs) are generally recognized as the most important therapeutic agent in some infectious diseases such as chronic hepatitis B and C. Since the early clinical trials it was documented that the therapeutic use of IFNs could be complicated by the development of antibodies able to neutralize or to bind to the IFN molecule.

After several years of research it is now widely accepted that the presence of circulating anti-IFN antibodies may affect the response to IFN.

Here we summarize what is currently know on the clinical significance of antibodies to IFN in IFN-treated viral diseases patients.

Key words

Antibodies to interferons hepatitis C hepatitis B interferons interferon alpha resistance to interferon 

Abbreviations

ALT

Alanine transaminase

ANB

Antiviral neutralization bioassay

IFN

Interferon

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • G. Antonelli
    • 1
  • E. Simeoni
    • 2
  • M. Currenti
    • 2
  • F. De Pisa
    • 3
  • V. Colizzi
    • 3
  • M. Pistello
    • 1
  • F. Dianzani
    • 2
  1. 1.Department of BiomedicineUniversity of PisaPisa
  2. 2.Instituto di VirologiaUniversità “La Sapienza”Roma
  3. 3.Department of BiologyUniversity “Tor Vergata”RomeItaly

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