Somatic Cell and Molecular Genetics

, Volume 24, Issue 1, pp 71–74

Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3

  • Kenneth E. White
  • Michael J. Econs
Brief Communication


A novel gene, PiUS, was recently cloned and shown to increase phosphate uptake when expressed in oocytes, indicating that it may be an important regulator of cellular phosphate homeostasis. The phosphate wasting disease autosomal dominant hypophosphatemic rickets (ADHR) was previously mapped to chromosome 12p13 by linkage analysis. PiUS’ role as a modulator of phosphate transport, as well as its intestinal and renal expression made the gene an appropriate candidate for ADHR. The purpose of our study was to determine the chromosomal localization of the human PiUS gene through the use of somatic cell hybrids and radiation hybrid mapping. In the present work, PiUS was localized to human chromosome 3q21.3 and is therefore not the ADHR gene.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature Cited

  1. 1.
    Norbis, F., Stange, G., Markovich, D., Verrey, F., Biber, J., and Murer, H. (1997). Identification of a cDNA/protein leading to an increased Pi-uptake in Xenopus laevis oocytes.J. Memb. Biol. 156:19–24.CrossRefGoogle Scholar
  2. 2.
    Econs, M.J., and McEnergy, P.T. (1997). Autosomal dominant hypophosphatemic rickets/osteomalacia: clinical characterization of a novel renal phosphate wasting disorder.J. Clin. Endocrinol. Metab 82:674–681.PubMedCrossRefGoogle Scholar
  3. 3.
    Econs, M.J., McEnery, P.T., Lennon, F., and Speer, M.C. (1997). Autosomal dominant hypophosphatemic rickets is linked to chromosome 12p13.J. Clin. Invest. 100:2653–2657.PubMedCrossRefGoogle Scholar
  4. 4.
    Drwinga, H.L., Toji, L.H., Kim, C.H., Greene, A.E., and Mulivor, R.A. (1993). NIGMS human/rodent somatic cell hybrid mapping panels 1 and 2.Genomics 16:311–314.PubMedCrossRefGoogle Scholar
  5. 5.
    Samson, M., Soularue, P., Vassart, G., and Parmentier, M. (1996). The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBRs5) are clustered in the p21.3–p24 region of chromosome 3.Genomics 36:522–526.PubMedCrossRefGoogle Scholar
  6. 6.
    Gazit, D., Tieder, M., Liberman, U.A., Passi-Even, L., and Bab, I.A. (1991). Osteomalacia in hereditary hypophosphatemic rickets with hypercalciuria: a correlative clinical-histomorphometric study.J. Clin. Endocrinol. Metab. 72:229–235.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Pubishing Corporation 1998

Authors and Affiliations

  • Kenneth E. White
    • 1
  • Michael J. Econs
    • 1
  1. 1.Department of MedicineIndiana University School of MedicineIndianapolis

Personalised recommendations