7Li 2D CSI of human brain on a clinical scanner

  • Franck Girard
  • Tetsuya Suhara
  • Takeshi Sassa
  • Yoshiro Okubo
  • Takayuki Obata
  • Hiroo Ikehira
  • Yasuhiko Sudo
  • Masahisa Koga
  • Hiroshi Yoshioka
  • Katsuya Yoshida
Article
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Abstract

Lithium salts have been widely used in the treatment of mood disorders, but the mechanism of action is still not clear. In this work, a methodology for two-dimensional Lithium-7 imaging on clinical systems is presented. The data were acquired using a phosphorus volume head coil that was re-tuned for the Lithium-7 frequency. A spectroscopic sequence was used to acquire the free induction decay (FID) after volume excitation using a hard pulse. The results obtained on the head of patients undergoing lithium treatment (n = 7, 0.6 mEq/1 average serum level) demonstrate that images of adequate signal to noise ratio (100:1) can be obtained in acceptable imaging times (55 min) using the proposed methodology. The distribution of ’’Li appears uniform in the brains of the patients studied.

Keywords

MR imaging Lithium-7 Psychiatry 
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Copyright information

© Elsevier Science B.V 2001

Authors and Affiliations

  • Franck Girard
    • 1
  • Tetsuya Suhara
    • 1
    • 2
  • Takeshi Sassa
    • 2
    • 3
  • Yoshiro Okubo
    • 2
    • 3
  • Takayuki Obata
    • 1
    • 2
  • Hiroo Ikehira
    • 1
  • Yasuhiko Sudo
    • 1
    • 2
  • Masahisa Koga
    • 1
  • Hiroshi Yoshioka
    • 1
  • Katsuya Yoshida
    • 1
  1. 1.Division of Medical ImagingNational Institute of Radiological SciencesChibaJapan
  2. 2.CREST (Core_ Research for Evolutional Science and Technology) of Japan Science and Technology CorporationTokyoJapan
  3. 3.Department of Neuropsychiatry Faculty of MedicineTokyo Medical & Dental UniversityTokyoJapan

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