Standardized MR protocol for the evaluation of MRA sequences and/or contrast agents effects in high-degree arterial stenosis analysis

  • Bruno MarchandEmail author
  • Philippe C. Douek
  • Philippe Robert
  • Claire Corot
  • Jean Pierre Roux
  • Patrice Adeleine
  • Marcela Hernandez-Hoyos
  • Yannick Cremillieux
  • Maciej Orkisz
  • Emmanuelle Canet



To investigate the relative role of high resolution (spatial or temporal) magnetic resonance angiography (MRA) sequence and of contrast agent properties in the evaluation of high-degree arterial stenosis.


We qualitatively and quantitatively studied both 50 and 95% (300 μm diameter) stenosis of a 6 mm arterial phantom with two contrast agents (CA), Gd-DOTA (r1 =2.9 mM−1 s−1) versus P760 (r1 =25 mM−1 s−1) at several CA concentrations, including arterial peak concentration after injection of either a single or double dose of CA, using either a high temporal (booster) or high spatial (HR) resolution 3D MRA sequences. Experimental data were then compared to theoretical data.


With the 3D HR sequence, both visual and quantitative analysis were significantly better compared to the 3D booster sequence, at each phantom diameter. Quantitative analysis was significantly improved by injection of a double versus a single dose of each CA (Gd-DOTA or P760), primarily in high degree stenosis.


Combined MRA spatial resolution and high CA efficiency are mandatory to correctly evaluate high degree stenosis.


Experimental study MR angiography Contrast agent Arteries Stenosis or obstruction Gadolinium 


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Copyright information

© Elsevier Science B.V 2002

Authors and Affiliations

  • Bruno Marchand
    • 1
    • 2
    Email author
  • Philippe C. Douek
    • 1
    • 3
  • Philippe Robert
    • 4
  • Claire Corot
    • 4
  • Jean Pierre Roux
    • 1
  • Patrice Adeleine
    • 5
  • Marcela Hernandez-Hoyos
    • 1
  • Yannick Cremillieux
    • 6
  • Maciej Orkisz
    • 1
  • Emmanuelle Canet
    • 1
  1. 1.Laboratoire CreatisUMR 5515. INSA 502VileurbanneFrance
  2. 2.Department of RadiologyHôpital de la Croix Rous.seLyonFrance
  3. 3.Department of RadiologyHôpital Cardiovasculaire Louis PradelBronFrance
  4. 4.GuerbetAulnay-sous-BoisFrance
  5. 5.Biostatistiques et Informatique MédicaleLyonFrance
  6. 6.Laboratoire de RMNUniversité Claude Bernard Lyon 1VilleurbanneFrance

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