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Inhibition of lens protein-, endotoxin- and interleukin-1-induced ocular inflammation with osthole and some other non-steroidal anti-Inflammatory agents

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Abstract

Anti-inflammatory actions of osthole and some other non-steroidal anti-inflammatory agents (NSAIA) were studied along with prednisolone on ocular inflammations induced by lens protein in rabbits and those induced by endotoxin or interleukin-1 (IL-1) in rats. It was found that ocular inflammation induced by lens protein at the anterior segment of the eyes can be inhibited by all agents tested, including osthole, mefenamic acid, indomethacin and norhydroguaiaretic acid. However, the posterior uveitis induced by endotoxin was inhibited only by osthole, mefenamic acid and prednisolone. IL-1-induced posterior uveitis was inhibited only by osthole and prednisolone. It is concluded that osthole is a unique agent for ocular inflammations, particularly for those which are difficult to treat, such as posterior uveitis.

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Authors and Affiliations

  1. Institute of Ocular Pharmacology, Department of Medical Pharmacology and Toxicology, Texas A & M University College of Medicine, College Station, 77843-1114, Texas, USA

    G. C. Y. Chiou, Q. S. Yao & B. H. P. Li

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  1. G. C. Y. Chiou
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  2. Q. S. Yao
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  3. B. H. P. Li
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Chiou, G.C.Y., Yao, Q.S. & Li, B.H.P. Inhibition of lens protein-, endotoxin- and interleukin-1-induced ocular inflammation with osthole and some other non-steroidal anti-Inflammatory agents. Inflammopharmacology 2, 5–13 (1993). https://doi.org/10.1007/BF02663737

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  • DOI: https://doi.org/10.1007/BF02663737

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