Diabetologia

, Volume 39, Issue 10, pp 1237–1238

Autoantibodies to IA-2 not detected in NOD mice or BB rats

  • M. G. DeSilva
  • H. S. Jun
  • J. W. Yoon
  • A. L. Notkins
  • M. S. Lan
Letter To The Editors

References

  1. 1.
    Lan MS, Lu J, Goto Y, Notkins AL (1994) Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 13: 505–514CrossRefPubMedGoogle Scholar
  2. 2.
    Payton MA, Hawkes CJ, Christie MR (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 96: 1506–1511CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Lu J, Li Q, Xie H et al. (1996) Identification of a second transmembrane protein tyrosine phosphatase, IA-2β, as an autoantigen in insulin-dependent diabetes mellitus: Precursor of the 37 kDa tryptic fragment. Proc Natl Acad Sci USA 93: 2307–2311CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Notkins AL, Maclaren NK, Wasserfall C, Lan MS (1995) IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in IDD. Autoimmunity 21: 49 A118 (Abstract)Google Scholar
  5. 5.
    Leslie RDG, Hawa M, Rowe W et al. (1995) Antibodies to a tyrosine phosphatase-like molecule precede and predict IDDM: an identical twin study. Autoimmunity 21: 60 A230 (Abstract)Google Scholar
  6. 6.
    Rossini AA, Handler ES, Mordes JP, Greiner DL (1995) Animal models of human disease. Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice. Clin Immunol Immunopathol 74: 2–9CrossRefPubMedGoogle Scholar
  7. 7.
    Lu J, Notkins AL, Lan MS (1994) Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase family. Biochem Biophys Res Commun 204: 930–936CrossRefPubMedGoogle Scholar
  8. 8.
    Passini N, Larigan JD, Genovese S, Appella E, Sinigaglia F, Rogge L (1995) The 37/40 kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2. Proc Natl Acad Sci USA 92: 9412–9416CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Bottazzo GF, Florin-Christensen A, Doniach D (1974) Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet ii: 1279–1283CrossRefGoogle Scholar
  10. 10.
    Palmer JP, Asplin CM, Clemons P et al. (1983) Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222: 1337–1339CrossRefPubMedGoogle Scholar
  11. 11.
    Baekkeskov S, Landin M, Kristensen JK et al. (1987) Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes. J Clin Invest 79: 926–934CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Atkinson MA, Maclaren NK (1988) Autoantibodies in nonobese diabetic mice immunoprecipitate 64,000-Mr islet antigen. Diabetes 37: 1587–1590CrossRefPubMedGoogle Scholar
  13. 13.
    Baekkeskov S, Dyrberg T, Lernmark A (1984) Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat. Science 224: 1348–1350CrossRefPubMedGoogle Scholar
  14. 14.
    Markholst H, Klaff LJ, Kloppel G, Lernmark A, Mordes JP, Palmer J (1990) Lack of systematically found insulin autoantibodies in spontaneously diabetic BB rats. Diabetes 39: 720–727CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • M. G. DeSilva
  • H. S. Jun
  • J. W. Yoon
  • A. L. Notkins
  • M. S. Lan
    • 1
  1. 1.Laboratory of Oral MedicineBethesdaUSA

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