Does N-acetylcysteine increase the excretion of trace metals (calcium, magnesium, iron, zinc and copper) when given orally?
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N-Acetylcysteine (NAC) is known to decrease the exacerbation rate in patients with chronic bronchitis. It has also been shown that NAC has both an oxygen-radical scavenger and a heavy-metal chelating effect in high intravenous doses. In a study lasting 5 weeks, 10 healthy volunteers were treated with NAC 200 mg t. d. s. for two weeks. The concentrations of trace metals (Ca, Mg, Fe, Zn & Cu) in plasma were measured weekly and daily in a morning spot urine during the investigation.
No significant change in plasma concentration or excretion was found during the two weeks of treatment, implying that additional administration of trace metals is unnecessary for patients treated perorally with a therapeutic dose of NAC.
Key wordsAcetylcysteine Metal excretion Trace metals NAC
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- 3.Kory RC, Hirsch RS, Giraldo J (1968) Nebulization of N-Ace- tylcysteine combined with a bronchodilator in patients with chronic bronchitis. Dis Chest 54:18–23Google Scholar
- 5.Jeffery P (1986) Anti-inflammatory drugs and experimental bronchitis. Eur J Respir Dis 69 [Supp1 146]: 245–257Google Scholar
- 10.Lorber A, Baumgartner WA, Bovy RA, Chang CC, Hollcraft R (1973) Ctincal application for heavy metal-complexing potential of N-Acetylcysteine. J Clin Pharmaco1 13:332–336Google Scholar
- 11.Gofrey NF, Peter A, Simon TM, Lorber A (1982) IV N-Ace- tylcysteine treatment of hematologic reactions to chrysotherapy. JRheumatol 9:519–526Google Scholar
- 12.Hjortsr E, Qvist J, Bud MIet al. (1988) ARDS after accidental inhalation of zinc chloride smoke. Int Care Med 27:522–525Google Scholar
- 14.Walser M (1961) Ion association. VII. Dependence of calciuresis on natriuresis during sulfate infusion. Am J Physio1 201:769–773Google Scholar