Osteoporosis International

, Volume 7, Issue 6, pp 533–538 | Cite as

Associations of vitamin C, calcium and protein with bone mass in postmenopausal Mexican American women

  • M. -C. Wang
  • M. Luz Villa
  • R. Marcus
  • J. L. Kelsey
Original Article


We investigated the associations of vitamin C, calcium and protein intakes with bone mass at the femoral neck and lumbar spine in postmenopausal Mexican American women. Bone mass was measured by dual-energy X-ray absorptiometry (DXA) and expressed as areal (BMD, g/cm2) and volumetric (bone mineral apparent density or BMAD, g/cm3) bone mineral density. Diet was assessed using a modified version of the National Cancer Institute Food Questionnaire, which was administered by trained bilingual interviewers familiar with Mexican dietary practices. Data gathered from 125 subjects were analyzed using multiple linear regression analysis with age, body mass index (BMI), acculturation, years of estrogen use, physical activity, total energy intake, and the nutrient of interest as independent variables. Neither calcium nor calcium/protein ratio was associated with bone mineral density. There was evidence of a positive association between dietary vitamin C intake and femoral neck BMD (β=0.0002 g/cm2 per mg/day, SE=0.0001,p=0.07) and BMAD (β=0.0001 g/cm3 per mg/day, SE=0.00006,p<0.05), but vitamin C was not associated with lumbar spine bone mass. Further investigation of the role of vitamin C in skeletal health is warranted.


Acculturation Bone mass Diet Mexican American Postmenopausal women Vitamin C 


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Copyright information

© European Foundation for Osteoporosis and the National Osteoporosis Foundation 1997

Authors and Affiliations

  • M. -C. Wang
    • 1
  • M. Luz Villa
    • 2
    • 3
  • R. Marcus
    • 2
    • 3
  • J. L. Kelsey
    • 1
    • 3
  1. 1.Division of Epidemiology, Department of Health Research and PolicyStanford University School of MedicineStanfordUSA
  2. 2.Department of MedicineStanford University School of MedicineStanford
  3. 3.Department of the Muskuloskeletal Research LaboratoryGeriatric Research, Education, and Clinical Center, Veteran Affairs Medical CenterPalo AltoUSA

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