γδ+ T cells in Wilson's diseaseT cells in Wilson's disease

  • U. Fiszer
  • G. Korczak-Kowalska
  • J. Gajda
  • J. Korlak
  • A. Górski
  • A. Członkowska


Little is currently known about the role of γδ+ + T cells in disease pathogenesis. We have demonstrated elevated levels of γδ+ T cells in the peripheral blood and cerebrospinal fluid of patients with Wilson's disease compared with other neurological diseases. The percentage of of γδ+ T cells was between 20% and 50% in all patient groups: of γδ+ T cells in blood correlated with copper concentrations. The antigen reactivity of γδ+ + T cells and how the antigens relate to the of γδ+ T cells found in WD remains unknown. It remains unclear whether there is a direct reason for the elevated of γδ+ T cells population found in WD. Immunohistochemistry of frozen autopsy material from brain and liver of WD patients could allow exact localization of γδ+ T cells and heat shock proteins in future studies.

Key words

Wilson's disease γδ+ T cells Heat shock proteins 


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • U. Fiszer
    • 1
  • G. Korczak-Kowalska
    • 2
  • J. Gajda
    • 1
  • J. Korlak
    • 1
  • A. Górski
    • 2
  • A. Członkowska
    • 1
  1. 1.II Department of NeurologyInstitute of Psychiatry and NeurologyWarsawPoland
  2. 2.Department of Immunology, Transplantation InstituteWarsaw Medical SchoolWarsawPoland

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