γδ+ T cells in Wilson's diseaseT cells in Wilson's disease
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Little is currently known about the role of γδ+ + T cells in disease pathogenesis. We have demonstrated elevated levels of γδ+ T cells in the peripheral blood and cerebrospinal fluid of patients with Wilson's disease compared with other neurological diseases. The percentage of of γδ+ T cells was between 20% and 50% in all patient groups: of γδ+ T cells in blood correlated with copper concentrations. The antigen reactivity of γδ+ + T cells and how the antigens relate to the of γδ+ T cells found in WD remains unknown. It remains unclear whether there is a direct reason for the elevated of γδ+ T cells population found in WD. Immunohistochemistry of frozen autopsy material from brain and liver of WD patients could allow exact localization of γδ+ T cells and heat shock proteins in future studies.
Key wordsWilson's disease γδ+ T cells Heat shock proteins
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