The effect of nonionic surfactant structure on hemolysis
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The hemolytic properties of polyoxyethylene-type nonionic surfactants were investigated in the concentration range of 0.1–5.0 wt/vol%. The effects of hydrophiliclipophilic balance, molecular weight, chemical structure and solubilizing ability of the nonionic surfactants in hemolysis are discussed. Bulky surfactants with three or four alkyl chains in their molecules, which show low solubilizing ability of lipids, were the least likely to induce hemolysis. Morphological observations of erythrocytes by video-enhanced microscopy showed that linear surfactants induce the formation of spherocytes and cause hemolysis, whereas bulky surfactants induce only morphological changes from discocytes to spheroechinocytes.
Key wordsBulky structure hemolysis morphological change nonionic surfactant
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- 1.Thron, C.D.,J. Pharmacol. 145:194 (1964).Google Scholar
- 2.Tragner, D., and A. Csordas,Biochem. J. 244:605 (1987).Google Scholar
- 8.Physicians’ Desk Reference, 45th edn., Medical Economics Co., Oredell, 1991, p. 1376.Google Scholar
- 10.Fukuda, M., M. Koide and K. Ohbu,J. Jpn. Oil Chem. Soc. 36:576 (1987).Google Scholar
- 11.Zaslavsky, B.Y., N.N. Ossipov, V.S. Krivich, L.P. Baholdina and S.V. Rogozhin, Ibid.:1 (1978).Google Scholar
- 12.Weltzien, H.V., Ibid.:6 (1973).Google Scholar
- 15.Handbook, Drug & Cosmetic Materials, edited by K. Hikime, Nikko Chemicals, Tokyo, 1977, pp. 880–893.Google Scholar
- 16.Kondo, M., M. Yoshimura and N. Okuyama,Seikagaku 44:849 (1972).Google Scholar
- 17.Lichtenberg, D., R.J. Robson and E.A. Dennis,Biochim. Biophys. Acta 737:285 (1983).Google Scholar