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Journal of the American Oil Chemists Society

, Volume 36, Issue 8, pp 322–325 | Cite as

Interrelations of linoleic acid with medium-chain and long-chain saturated triglycerides

  • Hans Kaunitz
  • Charles A. Slanetz
  • Ruth Ellen Johnson
  • Vigen K. Babayan
Technical

Summary

  1. 1.

    Effects of medium-chain (C6–C12) saturated triglycerides (MCT) and long-chain (C14–C18) saturated triglycerides (LCT) with and without linoleic acid (LA) supplementation were studied on rats fed purified diets

     
  2. 2.

    With 2% linoleic acid rats fed MCT and LCT grew somewhat better than those on a low-fat diet with the same supplement. Without linoleic acid those fed MCT grew better, and those fed LCT grew worse than those on the corresponding low-fat diet. MCT seemed to decrease, and LCT to increase linoleic acid requirements.

     
  3. 3.

    In survival studies 14 out of 18 rats fed 20% MCT were alive after 2 years; of their controls fed 20% lard, 10 out of 19 survived.

     
  4. 4.

    Reproduction studies in females gave equally poor results on unsupplemented low-fat, MCT, and LCT diets regarding implantation, birth weight, and survival rate. The weaning weights of the young on MCT were however the highest. With 2% LA weaning weights were equally high with LCT and MCT but lower with low-fat diet.

     
  5. 5.

    In animals fed low-fat diets not supplemented with LA, low serum cholesterol was associated with high liver cholesterol. With MCT, serum values were higher and liver values were significantly lower. With unsupplemented LCT, serum and liver values were high. When the three diets were supplemented with 2% LA, there were no longer any differences in the serum levels and in the liver levels. Whether ar not the presence of some oleate in the MCT and LCT influenced the cholesterol results is not certain.

     
  6. 6.

    The differences in the effects of MCT and LCT are discussed.

     

Keywords

Linoleie Acid Cocoa Butter Linoleic Acid Content Liver Cholesterol Oleie Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Alfin-Slater, R. B., Aftergood, L., Wells, A. F., and Deuel, H. J. Jr., Arch. Biochem. Biophys.,52, 180–186 (1954).CrossRefGoogle Scholar
  2. 2.
    Bloom, B., Chaikoff, I. L., and Reinhart, W. D., Am. J. Physiol.,166, 451–458 (1951).PubMedGoogle Scholar
  3. 3.
    Burr, G. O., Chem. and Med. IV, 101–121 (1940).Google Scholar
  4. 4.
    Burr, G. O., and Burr, M. M., J. Biol. Chem.,82, 345–365 (1929).Google Scholar
  5. 5.
    Burr, G. O., and Burr, M. M., J. Biol. Chem.,86, 587 (1930).Google Scholar
  6. 6.
    Channon, H. J., Jenkins, G. N., and Smith, J. A. B., Biochem. J.,31, 41–47 (1937).PubMedGoogle Scholar
  7. 7.
    Davis, K., J. Biol. Chem.,88, 67–71 (1930).Google Scholar
  8. 8.
    Eckstein, H., J. Biol. Chem.,84, 553–559 (1929).Google Scholar
  9. 9.
    Evans, H. M., Lepkovsky, S., and Murphy, E. A., J. Biol. Chem.,106, 441–444 (1934).Google Scholar
  10. 10.
    Furth, O. V., Beitr. Chem. Physiol. u. Path.,4, 430–441 (1903).Google Scholar
  11. 11.
    Hoagland, R., and Snider, G. G., J. Nutr.,22, 65–75 (1941).Google Scholar
  12. 12.
    Kaunitz, Hans, and Slanetz, C. A., J. Nutr.,42, 375–390 (1950).PubMedGoogle Scholar
  13. 13.
    Kaunitz, Hans, Slanetz, C. A., Johnson, R. E., and Guilmain, J., J. Nutr.,60, 221–231 (1956).PubMedGoogle Scholar
  14. 14.
    Kaunitz, Hans, Slanetz, C. A., Johnson, R. E., Babayan, V. K., and Barsky, G., J. Am. Oil Chemists' Soc.,35, 10–13 (1958).CrossRefGoogle Scholar
  15. 15.
    Kaunitz, Hans, Slanetz, C. A., Johnson, R. E., Babayan, V. K., and Barsky, G., J. Nutr.,64, 513–524 (1958).PubMedGoogle Scholar
  16. 16.
    Kelsey, F. F., and Longenecker, H. E., J. Biol. Chem.139, 727–735 (1941).Google Scholar
  17. 17.
    Keys, A., Anderson, J. T., and Grande, F., Lancet,272, 66–70 (1957).PubMedCrossRefGoogle Scholar
  18. 18.
    Loosli, J. K., Lingenfelter, J. F., Thomas, J. W., and Maynard, L. A., J. Nutr.,28, 81–89 (1944).Google Scholar
  19. 19.
    Maynard, L. A., and McCay, C. M., J. Nutr.,2, 67–74 (1929).Google Scholar
  20. 20.
    Meigs, E. B., Blatherwiek, N. R., and Cary, C. A., J. Biol. Chem.,37, 1–8 (1919).Google Scholar
  21. 21.
    Ozaki, J., Biochem. Ztschrft.,189, 233–243 (1929).Google Scholar
  22. 22.
    Scheer, B. T., Straub, E., Fields, M., Meserve, E., Hendrich, C., and Deuel, H. J. Jr., J. Nutr.,34, 581 (1947).Google Scholar
  23. 23.
    Schoenheimer, R., and Sperry, W. M., J. Biol. Chem.,106, 745–760 (1934).Google Scholar
  24. 24.
    Smedley-McLean, I., and Nunn, L. C. A., Biochem. J.,34, 884–890 (1940).Google Scholar
  25. 25.
    Sperry, W. M., and Webb, M., J. Biol. Chem.,187, 97–105 (1950).PubMedGoogle Scholar
  26. 26.
    Weitzel, G., Schoen, H., Gey, F., and Kalbe, H., Ztschrft. Physiol. Chem.,301, 118–123 (1955).Google Scholar

Copyright information

© The American Oil Chemists' Society 1959

Authors and Affiliations

  • Hans Kaunitz
    • 1
  • Charles A. Slanetz
    • 1
  • Ruth Ellen Johnson
    • 1
  • Vigen K. Babayan
    • 2
  1. 1.Department of Pathology and Institute of Comparative MedicineColumbia UniversityNew York
  2. 2.Research and Development LaboratoryE. F. Drew and Company Inc.Boonton

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