, 31:S77

Determinants of antioxidant status in humans

  • Andreas M. Papas
Antioxidant Status and Peroxidation


Antioxidant status in humans reflects the dynamic balance between the antioxidant system and prooxidants and has been suggested as a useful tool in estimating the risk of oxidative damage. This paper reviews determinants of antioxidant status such as diet including antioxidant nutrient and nonnutrient intake, absorption and bioavailabilty, dietary components such as polyunsaturated fatty acids and transition metals, food storage and processing, chemical form, chirality and formulation of supplemental compounds and alcohol intake; environmental factors such as pollutants, ultraviolet radiation and smoking; injury and disease, medications and other medical treatments such as radiation; strenuous exercise; and physiological stage or conditions such as those in premature babies and the elderly. It is proposed that, in addition to current focus on tissues, the antioxidant status of digesta should be considered because of its effect on specific tissues and potential health implications.



high density lipoproteins


hydrogen peroxide


hypochlorous acid


low density lipoproteins


oxides of nitrogen




singlet oxygen




polyunsaturated fatty acids


recommended dietary allowance






reactive oxygen-containing species




thiobarbituric acid-reactive substances


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Copyright information

© AOCS Press 1996

Authors and Affiliations

  • Andreas M. Papas
    • 1
  1. 1.Eastman Chemical CompanyKingsport

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