Lipids

, 31:S77

Determinants of antioxidant status in humans

  • Andreas M. Papas
Antioxidant Status and Peroxidation

Abstract

Antioxidant status in humans reflects the dynamic balance between the antioxidant system and prooxidants and has been suggested as a useful tool in estimating the risk of oxidative damage. This paper reviews determinants of antioxidant status such as diet including antioxidant nutrient and nonnutrient intake, absorption and bioavailabilty, dietary components such as polyunsaturated fatty acids and transition metals, food storage and processing, chemical form, chirality and formulation of supplemental compounds and alcohol intake; environmental factors such as pollutants, ultraviolet radiation and smoking; injury and disease, medications and other medical treatments such as radiation; strenuous exercise; and physiological stage or conditions such as those in premature babies and the elderly. It is proposed that, in addition to current focus on tissues, the antioxidant status of digesta should be considered because of its effect on specific tissues and potential health implications.

Abbreviations

HDL

high density lipoproteins

H2O2

hydrogen peroxide

HOCl

hypochlorous acid

LDL

low density lipoproteins

NO, NO2

oxides of nitrogen

O2

superoxide

1O2

singlet oxygen

OH

hydroxyl

PUFA

polyunsaturated fatty acids

RDA

recommended dietary allowance

O

alcoxyl

RO2

peroxyl

ROS

reactive oxygen-containing species

RS

thiyl

TBARS

thiobarbituric acid-reactive substances

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Copyright information

© AOCS Press 1996

Authors and Affiliations

  • Andreas M. Papas
    • 1
  1. 1.Eastman Chemical CompanyKingsport

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