Advertisement

Breast Cancer Research and Treatment

, Volume 18, Supplement 1, pp S23–S26 | Cite as

Endogenous hormones and breast cancer: A prospective cohort study

  • Paolo G. Toniolo
  • Bernard S. Pasternack
  • Roy E. Shore
  • Elizabeth Sonnenschein
  • Karen L. Koenig
  • Carl Rosenberg
  • Philip Strax
  • Selig Strax
Article

Summary

A cohort study is under way in New York City to evaluate how levels of endogenous reproductive hormones influence the risk of breast cancer. The study, in which approximately 15,000 women are being recruited, utilizes a prospective design in which volunteers are asked to provide repeated specimens of serum during the period 1985–1992. A case-control study nested within the cohort is planned by which specimens from all cases arising in the population and from a randomly selected sample of time-matched controls will be analyzed and compared. As of December 31, 1989, 13,609 volunteers had donated blood specimens, about 50% of whom had already donated more than once. Of the 187 incident breast cancer cases who are expected to arise in the cohort before the end of 1992, 77 have been detected thus far.

Key words

breast neoplasms estrogens prolactin prospective studies 

References

  1. 1.
    Zumoff B: Hormonal profiles in women with breast cancer (Review). Anticancer Research 8: 627–636, 1988PubMedGoogle Scholar
  2. 2.
    Mantel N: Synthetic retrospective studies and related topics. Biometrics 29: 479–486, 1973PubMedCrossRefGoogle Scholar
  3. 3.
    Liddel FDK, McDonald JC, Thomas DC: Methods for cohort analysis: appraisal by application to asbestos mining (with discussion). Royal Stat Soc 140: 469–491, 1977Google Scholar
  4. 4.
    Block G, Hartman AM, Dresser CM,et al.: A data-based approach to diet questionnaire design and testing. Am J Epidemiol 124: 453–469, 1986PubMedGoogle Scholar
  5. 5.
    Shore RE, Pasternack BS, Bulbrook RD,et al.: Endocrine and environmental factors in breast cancer: the case for prospective studies. Commentaries on Research in Breast Cancer 3: 1–31, 1983CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • Paolo G. Toniolo
    • 1
    • 2
  • Bernard S. Pasternack
    • 1
    • 2
  • Roy E. Shore
    • 1
    • 2
  • Elizabeth Sonnenschein
    • 1
  • Karen L. Koenig
    • 1
  • Carl Rosenberg
    • 1
  • Philip Strax
    • 3
  • Selig Strax
    • 3
  1. 1.Institute of Environmental MedicineNew York University Medical CenterNew YorkUSA
  2. 2.Kaplan Cancer CenterNew York University Medical CenterNew YorkUSA
  3. 3.The Guttman Breast Diagnostic InstituteNew YorkUSA

Personalised recommendations