Biological monitoring of deltamethrin exposure in greenhouses
- 46 Downloads
- 16 Citations
Abstract
This study examined the possibility of using biological monitoring to assess deltamethrin exposure among greenhouse workers. The synthetic pyrethroid deltamethrin was sprayed in five greenhouses by cold fog generators, and the exposure was biologically monitored by analysing the concentration of its metabolite, 3-phenoxybenzoic acid, by a gas chromatographic method after derivatization with pentafluorobenzyl bromide. 3-Phenoxybenzoic acid was found in the urine of two of the ten workers studied. The urine concentration of the metabolite varied from 2.4 to 51.7 μg/l. These results show that 3-phenoxybenzoic acid is suitable for biological monitoring for the assessment of exposure to deltamethrin.
Key words
Deltamethrin Cold fog generator Exposure Urinary metabolitePreview
Unable to display preview. Download preview PDF.
References
- He F, Wang S, Liu L, Chen S, Zhang Z, Sun J (1989) Clinical manifestations and diagnosis of acute pyrethroid poisoning. Arch Toxicol 63:54–58PubMedCrossRefGoogle Scholar
- Manninen A, Kangas J, Klen T, Savolainen H (1986) Exposure of Finnish farm workers to phenoxy acid herbicides. Arch Environ Contam Toxicol 15:107–111PubMedCrossRefGoogle Scholar
- Manninen A, Kangas J, Tuomainen A, Tahvonen R (1996) Exposure to insecticides in the use of cold fog generator in greenhouses. Toxicol Environm Chem (in press)Google Scholar
- Miyamoto J, Beynon K, Roberts T, Hemingway R, Swaine H (1981) The chemistry, metabolism and residue analysis of synthetic pyrethroids. Pure Appl Chem 53:1967–2022Google Scholar
- Ruzo L, Engel J, Casida J (1978) Decamethrin metabolites from oxidative, hydrolytic and conjugative reactions in mice. J Agric Food Chem 27:725–731CrossRefGoogle Scholar
- Ruzo L, Unai T, Casida J (1979) Decamethrin metabolism in rats. J Agric Food Chem 26:918–925CrossRefGoogle Scholar
- Vaysse M, Giudicelli J, Devarex P, L'Hotellier M (1984) Decis: analytical methods for pesticides and plant growth regulators, vol XIII. Academic Press, New York, pp 53–68Google Scholar
- Vijverberg H, Van den Bercken J (1982) Action of pyrethroid insecticides on the vertebrate nervous system. Neuropathol Appl Neurobiol 8:421–440PubMedGoogle Scholar
- Worthing CR, Hance RJ (eds) (1991) The Pesticide Manual: a world compendium, 9th Ed. British Crop Protection Council. Surrey, UKGoogle Scholar
- Wu Y, Xiao-Yen G, Chun-Ling L (1994) Determination of pyrethroids in human urine by gas chromatography. Biomed Environm Sci 7:216–221Google Scholar
- Yao P, Li Y, Zhang X, He F (1989) Biological monitoring of deltamethrin metabolites in spraymen and one suicide patient by HPLC. In: Sakurai H (ed.) VII Int Conf Epidemiology in Occupational Health. Tokyo October, Elsevier Science Publishers, Amsterdam, pp 219–222Google Scholar
- Yao P, Li Y, Ding Y, He F (1992) Biological monitoring of deltamethrin in sprayers by HPLC method. J Hyg Epidemiol Microbiol Immunol 1:31–36Google Scholar
- Zhang Z, Sun J, Chen S, Wu Y, He F (1991) Levels of exposure and biological monitoring of pyrethroids in spraymen. Br J Ind Med 48:82–86PubMedGoogle Scholar