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Biotherapy

, Volume 9, Issue 1–3, pp 87–90 | Cite as

Lessons from a pilot study of transfer factor in chronic fatigue syndrome

  • Caterina De Vinci
  • Paul H. Levine
  • Giancarlo Pizza
  • Hugh H. Fudenberg
  • Perry Orens
  • Gary Pearson
  • Dimitri Viza
Article

Abstract

Transfer Factor (TF) was used in a placebo controlled pilot study of 20 patients with chronic fatigue syndrome (CFS). Efficacy of the treatment was evaluated by clinical monitoring and testing for antibodies to Epstein-Barr virus (EBV) and human herpes virus-6 (HHV-6). Of the 20 patients in the placebo-controlled trial, improvement was observed in 12 patients, generally within 3-6 weeks of beginning treatment. Herpes virus serology seldom correlated with clinical response. This study provided experience with oral TF, useful in designing a larger placebo-controlled clinical trial.

Key words

CMV chronic fatigue syndrome EBV herpes viruses HHV-6 transfer factor 

Abbreviations

CFS

chronic fatigue syndrome

CMV

cytomegalovirus

EBV

Epstein-Barr virus

EBV-EA

EBV-early antigens

EBV-VCA

EBV-Viral capsid antigen

HHV-6

human herpes virus-6

HSV

Herpes simplex virus

TF

transfer factor

NTF

non-specific transfer factor

pt

patient

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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Caterina De Vinci
    • 5
  • Paul H. Levine
    • 1
  • Giancarlo Pizza
    • 5
  • Hugh H. Fudenberg
    • 2
  • Perry Orens
    • 3
  • Gary Pearson
    • 1
  • Dimitri Viza
    • 4
  1. 1.Georgetown UniversityWashington DCUSA
  2. 2.NeuroImmuno Therapeutics FoundationSpartanburgUSA
  3. 3.Great NeckNew YorkUSA
  4. 4.Laboratoire d’Immunobiologie, URA 1294 CNRSFaculté de MédecineParisFrance
  5. 5.Immunodiagnosis and Immunotherapy Unit, 1st Division of UrologySant’ Orsola-Malpighi HospitalBolognaItaly

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