Acta diabetologia latina

, Volume 25, Issue 3, pp 247–256 | Cite as

Blood lactate behavior after glucose load in diabetes mellitus

  • Romano Prando
  • Valeria Cheli
  • Paolo Buzzo
  • Plerluigi Melga
  • Egle Ansaldi
  • Salvatore Accoto
Original Contributions
Received:

Summary

The aim of this study was to evaluate the relationships between blood lactate and plasma glucose, insulin (IRI) and C-peptide (IRCP) during the first hour of an oral glucose load (OGTT, 100 g). Twelve controls, sixteen non-insulin-dependent (NIDDM) and four insulin-dependent (IDDM) diabetic subjects were studied. A significant increase in blood lactate was observed at 15 min in normal subjects, whereas there was a delayed increase at 45 min in NIDDM subjects, in the presence of IRCP increments of 0.31 nmol/l. In order to have a minimum significant lactate increment, the threshold value of peripheral IRCP increment was about 0.30 nmol/l. In IDDM subjects, despite considerable hyperglycemia, blood lactate concentration remained unchanged throughout the test. In normal and NIDDM subjects there was a significant negative correlation between Δ lactate and Δ glucose (r=−0.89, p<0.001) and a significant positive correlation between Δ lactate and Δ IRCP (r=0.78, p<0.001). In conclusion, hyperglycemia itself and the lack of increase in insulin secretion do not affect blood lactate increase during OGTT; blood concentration of this metabolite depends mainly on an early insulin secretion apt to enhance tissue glucose uptake and to inhibit gluconeogenesis.

Key-words

Blood lactate C-peptide Diabetes mellitus Insulin Plasma glucose 
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Copyright information

© Casa Editrice «il Ponte» 1988

Authors and Affiliations

  • Romano Prando
    • 1
  • Valeria Cheli
    • 1
  • Paolo Buzzo
    • 1
  • Plerluigi Melga
    • 1
  • Egle Ansaldi
    • 1
  • Salvatore Accoto
    • 1
  1. 1.Istituto Scientifico di Medicina Interna Cattedra di Malattie del RicambioUniversità di GenovaGenovaItaly

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