In Vitro

, Volume 13, Issue 10, pp 648–661 | Cite as

The scientific imperative for use of human cells and organs in vitro: Comparative toxicology and oncogenesis

  • T. Timothy Crocker
Article

Keywords

Aflatoxin Organ Culture DMBA Polycyclic Hydrocarbon Human Fetal Lung 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Heidelberger, C. 1973. Chemical oncogenesis in culture. Adv. Cancer Res. 181: 317–366.CrossRefGoogle Scholar
  2. 2.
    Diamond, L. 1971. Metabolism of polycyclic hydrocarbons in mammalian cell cultures. Int. J. Cancer 8: 451–462.PubMedGoogle Scholar
  3. 3.
    Crocker, T. T., and E. R. Dirksen. 1975. Metaplasias induced by benzo(a)pyrene in human respiratory epithelium. Part I. In: A. J. Finkel, and W. C. Duel (Eds.),Clinical Implications of Air Pollution Research, Publishing Sciences Group, Inc., Acton, Mass.Google Scholar
  4. 4.
    Dirksen, E. R., and T. T. Crocker. 1972. Fine structural changes produced by benzo(a)pyrene on human respiratory epithelium in organ culture. In: C. J. Arcenaux (Ed.),30th Ann. Proc. Electron Microscopy Soc. Amer. Los Angeles.Google Scholar
  5. 5.
    Crocker, T. T., T. V. O'Donnell, and L. L. Numes 1973. Toxicity of benzo(a)pyrene and air pollution composite for adult human bronchial mucosa in organ culture. Cancer Res. 33: 88–93.PubMedGoogle Scholar
  6. 6.
    Fox, C. H., J. F. Selkirk, F. M. Price, R. G. Gray, K. K. Sanford, and M. Cottler-Fox. 1975. Metabolism of benzo(a)pyrene by human epithelial cellsin vitro. Cancer Res. 28: 906–923.Google Scholar
  7. 7.
    Stich, H. F., and B. A. Laishes. 1973. DNA repair and chemical carcinogens. In: H. L. Ioachim (Ed.),Pathobiology Annual. AUTHOR—supply publisher, city, pp. 341–376.Google Scholar
  8. 8.
    Sans, R. H. C., and H. F. Stich 1975. DNA repair synthesis of cultured human cells as a rapid bioassay for chemical carcinogens. Int. J. Cancer 16: 284–291.CrossRefGoogle Scholar
  9. 9.
    DiPaolo, J. A. 1974. Quantitative aspects of in vitro chemical carcinogenesis. In: P. O. P. T'so, and J. A. diPaolo (Eds.),Chemical Carcinogenesis, Marcel Dekker, Inc., New York, pp. 443–456.Google Scholar
  10. 10.
    Crocker, T. T. 1970. Effect of benzo(a)pyrene on hamster, rat dog and monkey respiratory epithelia in organ culture. In: M. G. Hanna, Jr., P. Nettesheim, and J. R. Gilbert (Eds.),Inhalation Carcinogenesis. Proceedings of Biology Division, Oak Ridge National Laboratory, pp. 433–443. (AEC Symposium Series 18, AEC Division of Technical Information.)Google Scholar
  11. 11.
    Crocker, T. T., B. I. Nielson, and I. Lasnitzki. 1965. Carcinogenic hydrocarbons: effect on suckling rat trachea in organ culture. Arch. Environ. Health 10: 240–250.PubMedGoogle Scholar
  12. 12.
    Lasnitzki, I. 1956. The effect of 3,4-benzpyrene on human foetal lung grownin vitro. Br. J. Cancer 10: 510–516.PubMedGoogle Scholar
  13. 13.
    Lasnitzki, I. 1958. Observations on the effects of condensates from cigarette smoke on human foetal lungin vitro. Br. J. Cancer 12: 547–552.PubMedGoogle Scholar
  14. 14.
    Lasnitzki, I. 1968. The effect of a hydrocarbon-enriched fraction of cigarette smoke condensate on human fetal lung grownin vitro. Cancer Res., 28: 510–516.PubMedGoogle Scholar
  15. 15.
    Lasnitzki, I. 1951. Precancerous changes induced by methylcholanthrene in mouse prostates grownin vitro. Br. J. Cancer 5: 345–352.PubMedGoogle Scholar
  16. 16.
    Lasnitzki, I. 1968: The effect of a hydrocarbon enriched fraction from cigarette smoke on mouse tracheas grownin vitro. Br. J. Cancer 5: 345–352.Google Scholar
  17. 16a.
    Lasnitzki, I. 1968. The effect of a hydrocarbon enriched fraction from cigarette smoke on mouse tracheas grownin vitro. Br. J. Cancer 22: 105–109.PubMedGoogle Scholar
  18. 17.
    Röller, M. K., and C. Heidelberger. 1967. Attempts to produce carcinogenesis in organ cultures of mouse prostate with polycyclic hydrocarbons. Int. J. Cancer 2: 509–520.PubMedCrossRefGoogle Scholar
  19. 18.
    Shabad, L. M., T. S. Kolesnichenko, and N. I. Golub. 1975. The effect produced by some carcinogenic nitrosompounds on organ cultures from human embryonic lung and kidney tissues. Int. J. Cancer 16: 768–778.PubMedCrossRefGoogle Scholar
  20. 19.
    Igel, H. J., A. E. Freeman, J. E. Spiewak, and K. L. Kleinfeld. 1975. Carcinogenesis in vitro. II. Chemical transformation of human diploid cell cultures: a rare event. In Vitro 11: 117–129.PubMedGoogle Scholar
  21. 20.
    Sato, J., M. Namba, K. Usui, and D. Nagano. 1968. Carcinogenesis in tissue culture. VIII. Spontaneous malignant transformation of rat liver cells in long term culture. Jap. J. Exp. Med. 38: 105–118.PubMedGoogle Scholar
  22. 21.
    Oshiro, Y., L. E. Gerschenson, and J. A. DiPaolo. 1972. Carcinomas from rat liver cells transformed spontaneously in culture. Cancer Res. 32: 877–879.PubMedGoogle Scholar
  23. 22.
    Weinstein, I. B., N. Yamaguchi, and R. Gebert. 1975. Use of epithelial cell cultures for studies on the mechanism of transformation by chemical carcinogens. In Vitro 11: 130–141.PubMedGoogle Scholar
  24. 23.
    Williams, G. C., J. M. Elliott, and J. H. Weisburger. 1973. Carcinoma after malignant conversionin vitro of epithelial-like cells from rat liver following exposure to chemical carcinogens. Cancer Res. 33: 606–612.PubMedGoogle Scholar
  25. 24.
    Montesano, R., L. Saint Vincent, and L. Tomatis. 1973. Malignant transformationin vitro of rat liver cells by dimethylnitrosamine and N-methyl-N1-nitro-N-nitrosoguanidine. Br. J. Cancer 28: 215–220.PubMedGoogle Scholar
  26. 25.
    Selkirk, J. K., R. G. Croy, J. P. Whitlock, Jr., and H. V. Gelboin. 1975.In vitro metabolism of benzo(a)pyrene by human liber microsomes and lymphocytes. Cancer Res. 25: 3651–3655.Google Scholar
  27. 26.
    Wang, I. Y., R. E. Rasmussen, R. K. Creasy, and T. T. Crocker. 1976. Effect of cigarette smoking on the metabolism of benzo(a)pyrene by human placental microsomes, submitted for publication.Google Scholar
  28. 27.
    Kellerman, G., C. R. Shaw, and M. Luyten-Kellerman. 1973. Aryl hydrocarbon hydroxyglase inducibility and bronchogenic carcinoma. N. Engl. J. Med. 289: 934–937.CrossRefGoogle Scholar
  29. 28.
    Wang, I. Y., R. E. Rasmussen, and T. T. Crocker. 1974. Metabolism of benzo(a)pyrene by microsomes from tissues of pregnant and fetal hamsters. Life Sci. 15: 1291–1300.PubMedCrossRefGoogle Scholar
  30. 29.
    Dirksen, E. R., and T. T. Crocker. 1968. Ultrastructural alterations produced by polycyclic aromatic hydrocarbons on rat tracheal epithelium in organ culture. Cancer Res. 28: 906–923.PubMedGoogle Scholar
  31. 30.
    Dao, T. L., and D. Sinha. 1972. Mammary adenocarcinoma induced in organ culture by 7,12-dimethylbenzanthrocene. J. Natl. Cancer Inst. 49: 591.PubMedGoogle Scholar

Copyright information

© Tissue Culture Association 1977

Authors and Affiliations

  • T. Timothy Crocker
    • 1
  1. 1.Department of Community and Environmental Medicine, College of MedicineUniversity of CaliforniaIrvine

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