Journal of Molecular Evolution

, Volume 25, Issue 4, pp 330–342 | Cite as

An evaluation of the molecular clock hypothesis using mammalian DNA sequences

  • Wen-Hsiung Li
  • Masako Tanimura
  • Paul M. Sharp
Article

Summary

A statistical analysis of extensive DNA sequence data from primates, rodents, and artiodacytls clearly indicates that no global molecular clock exists in mammals. Rates of nucleotide subsitution in rodents are estimated to be four to eight times higher than those in higher primates and two to four times higher than those in artiodactyls. There is strong evidence for lower substitution rates in apes and humans than in monkeys, supporting the hominoid slowdown hypothesis. There is also evidence for lower rates in humans than in apes, suggesting a further rate slowdown in the human lineage after the separation of humans from apes. By contrast, substitution rates are nearly equal in mouse and rat. These results suggest that differences in generation time or, more precisely, in the number of germline DNA replications per year are the primary cause of rate differences in mammals. Further, these differences are more in line with the neutral mutation hypothesis than if the rates are the same for short-and long-living mammals.

Key words

Molecular clock Generation-time effect Hominoid slowdown Hominid slowdown Neutral theory 
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • Wen-Hsiung Li
    • 1
  • Masako Tanimura
    • 1
  • Paul M. Sharp
    • 1
    • 2
  1. 1.Center for Demographic and Population GeneticsUniversity of TexasHoustonUSA
  2. 2.Department of GeneticsTrinity CollegeDublinIreland

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