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CardioVascular and Interventional Radiology

, Volume 16, Issue 1, pp 14–20 | Cite as

Transcatheter arterial infusion therapy combined with radical hysterectomy in the treatment of advanced cervical cancer

  • Yasushi Nagata
  • Takashi Ishigaki
  • Kaoru Okajima
  • Kazuhisa Fujiwara
  • Tomoko Kinashi
  • Mitihide Mitumori
  • Natuo Ooya
  • Yosizumi Kitakabu
  • Masahiro Hiraoka
  • Mitsuyuki Abe
  • Kenji Takokura
  • Ikuo Konishi
  • Ichirou Takai
  • Shunzou Taii
  • Takehide Mori
  • S. Wallace
  • J. J. Kavanagh
  • C. H. Carrasco
  • Yashushi Nagata
Clinical Investigations

Abstract

Two or three sessions of transcatheter arterial infusion (TAI) therapy were performed preoperatively in 13 patients with advanced cervical cancer (stage 3 or more). The efficacy of TAI was evaluated by tumor markers, magnetic resonance imaging (MRI), and postoperative histopathological examination. In all cases, tumor marker levels decreased after TAI therapy, and MRI also showed a decrease in the tumor size in 11/12 patients. The tumor tissue resected at radical hysterectomy showed no viable cancer cells in 6 patients, and no viable extrauterine cancer was detected in 5 more patients. Thus, TAI performed via both internal iliac arteries reduced both tumor size and extension to the parametrium, and it appears to have the potential to be an effective treatment modality for advanced cervical cancer.

Key words

Advanced cervical cancer Transcatheter arterial infusion MRI Radiotherapy Radical hysterectomy 
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Copyright information

© Springer-Verlag New York Inc 1993

Authors and Affiliations

  • Yasushi Nagata
    • 1
  • Takashi Ishigaki
    • 1
  • Kaoru Okajima
    • 1
  • Kazuhisa Fujiwara
    • 1
  • Tomoko Kinashi
    • 1
  • Mitihide Mitumori
    • 1
  • Natuo Ooya
    • 1
  • Yosizumi Kitakabu
    • 1
  • Masahiro Hiraoka
    • 1
  • Mitsuyuki Abe
    • 1
  • Kenji Takokura
    • 1
  • Ikuo Konishi
    • 2
  • Ichirou Takai
    • 2
  • Shunzou Taii
    • 2
  • Takehide Mori
    • 2
  • S. Wallace
    • 3
  • J. J. Kavanagh
    • 4
  • C. H. Carrasco
    • 3
  • Yashushi Nagata
    • 5
  1. 1.Department of RadiologyKyoto University HospitalSakyo KyotoJapan
  2. 2.Department of Gynecology and ObstetricsKyoto University HospitalSakyo KyotoJapan
  3. 3.Department of Diagnostic RadiologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA
  4. 4.Department of Gynecologic OncologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA
  5. 5.Kyoto University HospitalSakyo KyotoJapan

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