Journal of General Internal Medicine

, Volume 11, Issue 12, pp 744–749 | Cite as

Does treatment withl-thyroxine influence health status in middle-aged and older adults with subclinical hypothyroidism?

  • Roman Jaeschke
  • Gordon Guyatt
  • Hertzel Gerstein
  • Christopher Patterson
  • William Molloy
  • Deborah Cook
  • Sandra Harper
  • Lauren Griffith
  • Ramona Carbotte
Original Articles


OBJECTIVE: To determine if health-related quality of life (HRQL) in patients of middle age and older with elevated thyroid-stimulating hormone (TSH) and normal total thyroid hormone levels—subclinical hypothyroidism—improves withl-thyroxine replacement therapy.

DESIGN: Randomized, double-blind, placebo-controlled trial.

SETTING: Outpatient clinic.

PATIENTS: Thirty-seven patients with subclinical hypothyroidism, most with symptoms consistent with hypothyroidism, over 55 years of age.

INTERVEJVTIOJVS: Placebo or L-thyroxine replacement therapy to achieve normal TSH level.

MEASUREMENTS AND MAIN RESULTS: Disease-specific and general HRQL, cognitive function, bone mineral density, lipid levels. The mean daily dose of L-thyroxine replacement in the active group was 68±21 µg. TSH decreased by 8.6 mIU/L (95% confidence interval [CI] 4.1 to 13.1) and T4 increased by 27.9 nmol/L (95% CI 14.8 to 41.2). There was a statistically significant improvement in a composite psychometric memory score in treated versus control patients; all other outcomes showed similar findings in the two groups. Although confidence intervals for most measures did not exclude an important improvement in HRQL with thyroid replacement, no measure of symptoms or HRQL either showed clinically important trends in favor of treatment, or approached conventional levels of statistical significance.

CONCLUSIONS: In middle-aged and older patients with elevated TSH and normal T4, it may not be harmful to follow biochemical and clinical status even in the presence of nonspecific symptoms potentially associated with hypothyroidism.

Key words

Subclinical hypothyroidism quality of life elderly 


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Copyright information

© Blackwell Science, Inc. 1996

Authors and Affiliations

  • Roman Jaeschke
    • 1
    • 4
  • Gordon Guyatt
    • 1
    • 2
  • Hertzel Gerstein
    • 1
  • Christopher Patterson
    • 1
  • William Molloy
    • 1
  • Deborah Cook
    • 1
    • 2
    • 4
  • Sandra Harper
  • Lauren Griffith
    • 2
  • Ramona Carbotte
    • 3
  1. 1.the Department of MedicineMcMaster UniversityCanada
  2. 2.the Department of Clinical Epidemiology and BiostatisticsMcMaster UniversityCanada
  3. 3.the Department of PsychiatryMcMaster UniversityCanada
  4. 4.Department of MedicineSt. Joseph’s HospitalHamiltonCanada

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