Contrast-enhanced pulmonary MR imaging



The present paper reports our own experience with MR perfusion imaging and gives an overview of contrast-enhanced pulmonary MR perfusion imaging, MR angiography, and ventilation MR imaging using hyperpolarized gases or oxygen as contrast agent. These methods are discussed within the context of their possible role in the diagnosis of pulmonary diseases, particularly embolism and emphysema.


Pulmonary magnetic resonance imaging Lung ventilation imaging Lung perfusion imaging Hyperpolarized gases Oxygen imaging Pulmonary embolism Emphysema 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Lauterbur PC. Feasibility of NRM zeugmatographic imaging of the heart and lungs. In: Preston K, Taylor JW, Johnson SA, Ayers WR, editors. Medical Imaging Techniques. New York: Plenum, 1979:209–18.Google Scholar
  2. [2]
    Alsop DC, Hatabu H, Bonnet, M, Listerud J, Gefter W. Multislice breathhold imaging of the lung with submillisecond echotimes. Magn Reson Med 1995;33:678–92.PubMedCrossRefGoogle Scholar
  3. [3]
    Hatabu H. MR pulmonary angiography and perfusion imaging: recent advances. Semin Ultrasound CT MR 1997;18:349–61.PubMedCrossRefGoogle Scholar
  4. [4]
    Rinck PA, Petersen SB, Lauterbur PC. NMR-Imaging von fluorhaltigen Substanzen. 19-Fluor Ventilations- und-Perfusionsdarstellungen. Röfö Fortschr Röntgenstr 1984;140:239–43.CrossRefGoogle Scholar
  5. [5]
    Hansson P-O, Welin L, Tibblin G, Eriksson H. Deep vein thrombosis and pulmonary embolism in the general population. ‘The study of men born in 1913’. Arch Intern Med 1997;157:1665–70.PubMedCrossRefGoogle Scholar
  6. [6]
    Amundsen T, Kværness J, Jones RA, Waage A, Bjermer L, Nilsen G, Haraldseth O. Pulmonary embolism: detection with MR perfusion imaging of lung—a feasibility study. Radiology 1997;203:181–5.PubMedGoogle Scholar
  7. [7]
    Hennig J, Scheffler K, Laubenberger J, Strecker R. Time-resolved projection angiography after bolus injection of contrast agent. Magn Reson Med 1997;37:341–5.PubMedCrossRefGoogle Scholar
  8. [8]
    Wang Y, Johnston DL, Breen JF, Huston J III, Jack CR, Julsrud PR, Kiely MJ, King BF, Riederer SL, Ehman RL. Dynamic MR digital subtraction angiography using contrast enhancement, fast data acquisition, and complex subtraction. Magn Reson Med 1996;36:551–6.PubMedCrossRefGoogle Scholar
  9. [9]
    Meaney JFM, Weg JG, Chenevert L, Stafford-Johnson D, Hamilton BH, Prince MR. Diagnosis of pulmonary embolism with magnetic resonance angiography. New Engl J Med 1997;336:1422–7.PubMedCrossRefGoogle Scholar
  10. [10]
    Wielopolski PA, Hicks S, de Bruin H, Oudkerk M. Localizing pulmonary emboli: combining breath-hold three-dimensional lung perfusion imaging and 512 matrix pulmonary angiography after contrast administration. In: Proceedings of the International Society of Magnetic Resonance Medicine, Fifth Scientific Meeting, 1997 Abstract 130.Google Scholar
  11. [11]
    Riederer SJ, Kruger DG, Wilman AH, Rossman PJ, Huston J, Ehman RL, Breen JF, LaPlante CL. Contrast-enhanced 3D MR angiography using fluoroscopic triggering: technical reliability and applicability in 250 patients. In: Proceedings of the International Society of Magnetic Resonance Medicine, Sixth Scientific Meeting, 1998 Abstract 169.Google Scholar
  12. [12]
    Wilman AH, Riederer SJ. Performance of an elliptical centric view order for signal enhancement and motion artifact suppression in breath-hold three-dimensional gradient echo imaging. Magn Reson Med 1997;38:793–802.PubMedCrossRefGoogle Scholar
  13. [13]
    Ahlstrøm H, Johansson L, Ragnarsson A, Børseth A. Pulmonary MRA during continuous breathing using a blood pool agent and navigator echo. In: Proceedings of the International Society of Magnetic Resonance Medicine, Sixth Scientific Meeting, 1998 Abstract 170.Google Scholar
  14. [14]
    Wang Y, Rossman PJ, Grimm RC, Wilman AH, Riederer SJ, Ehman RL. 3D MR angiography of pulmonary arteries using real-time navigator gating and magnetization preparation. Magn Reson Med 1996;36:579–87.PubMedCrossRefGoogle Scholar
  15. [15]
    Misselwitz B, Mühler A, Heinzelmann I, Bock JC, Weinmann HJ. Magnetic resonance imaging of pulmonary ventilation. Initial experiences with a gadolinium-DTPA-based aerosol. Invest Radiol 1997;32:797–801.PubMedCrossRefGoogle Scholar
  16. [16]
    Kauczor H, Surkau R, Roberts T. MRI using hyperpolarized noble gases. Eur Radiol 1998;8:820–7.PubMedCrossRefGoogle Scholar
  17. [17]
    MacFall JR, Charles HC, Black RD, Middleton H, Swartz JC, Saam B, Driehuys B, Erickson C, Happer W, Cates GD, Johnson GA, Ravin CE. Human lung air spaces: potential for MR imaging with hyperpolarized He-3. Radiology 1996;200:553–8.PubMedGoogle Scholar
  18. [18]
    de Lange EE, Mugler III JP, Brookeman JR, Daniel TM, Truwit JD, Teates CD, Knight-Scott J. MR imaging of the lungs with hyperpolarized helium-3 gas. In: Proceedings of the International Society of Magnetic Resonance Medicine, Sixth Scientific Meeting, 1998 Abstract 445.Google Scholar
  19. [19]
    Schad LR, Bachert P, Bock M, Essig M, Knopp MV, Ebert M, Grossmann T, Heil W, Surkau R, Otten EW. Hyperpolarized gases—a new type of MR contrast agents. Acta Radiol 1997;38(Suppl 412):43–6.Google Scholar
  20. [20]
    Durand E, Darasse L, Guillot G, Nacher P-J, Tastevin G. Fast low field MRI of hyperpolarized3He in human lungs. Magn Reson Mat Phys Biol Med 1998;6(Suppl 1):101.Google Scholar
  21. [21]
    Crémillieux Y, Berthezène Y, Humbolt H, Viallon M, Canet E, Bourgeois M, Albert T, Heil W, Briguet A. Proton perfusion/helium ventilation imaging in rat lungs. Magn Reson Mat Phys Biol Med 1998;6(Suppl 1):102–3.Google Scholar
  22. [22]
    Mugler III JP, Brookeman JR, Knight-Scott J, Maier T, de Lange EE, Bogorad PL. Interleaved echo-planar imaging of the lungs with hyperpolarized3He. In: Proceedings International Society Magnetic Resonance Medicine, Sixth Scientific Meeting, 1998 Abstract 448.Google Scholar
  23. [23]
    Edelman RR, Hatabu H, Tadamura E, Li W, Prasad PV. Noninvasive assessment of regional ventilation in human lung using oxygen-enhanced magnetic resonance imaging. Nature Med 1996;2:1236–9.PubMedCrossRefGoogle Scholar
  24. [24]
    Jakob PM, Chen Q, Griswold M, Edelman R. Optimized MR ventilation imaging of the lung. Magn Reson Mat Phys Biol Med 1998;6(Suppl 1):99.Google Scholar
  25. [25]
    Penzkofer H, Löffler R, Peller M, Mueller-Lisse U, Deimling M, Scholz V, Reiser M. Multisection ventilation imaging of the human lung after breathing of 100% oxygen. In: Proceedings of the International Society Magnetic Resonance Medicine, Sixth Scientific Meeting, 1998 Abstract 454.Google Scholar

Copyright information

© Elsevier Science B.V. All rights reserved 1999

Authors and Affiliations

  • Olav Haraldseth
    • 1
  • Tore Amundsen
    • 1
  • Peter A. Rinck
    • 2
  1. 1.MR-CenterTrondheimNorway
  2. 2.Medical Faculty, NMR Laboratory, Medical Image Processing GroupUniversity of Mons-HainautMonsBelgium

Personalised recommendations