Lasers in Medical Science

, Volume 7, Issue 1–4, pp 433–439 | Cite as

Low power interstitial Nd-YAG laser photocoagulation in normal rabbit brain

  • Stanley W. Schatz
  • Stephen G. Bown
  • Douglas R. Wyman
  • John T. Groves
  • Brian C. Wilson


The safe, effective, clinical application of interstitial laser irradiation to destroy brain tumour tissue requires a knowledge of the relation of the extent of laser-induced (thermal) necrosis to the delivered laser power and total energy, and to time post-irradiation. We have conducted experiments to determine these relationships in normal rabbit brain. Irradiation by a Nd-YAG laser (1064 nm), at powers of 0.5–3.0 W and exposures of 200–1333 s produced well-defined necrotic lesions whose size increased with both the power and the total energy delivered. Lesions of 6 mm diameter made by 0.75 W for 1000s were well tolerated by animals allowed to recover from anaesthesia following irradiation. The diameter of the lesion was greatest at 48 h after irradiation. Following evolution of a characteristic healing response to necrosis in brain, the residual damage at 4 weeks was no greater in volume than that of the acute lesion. The results suggest that low power interstitial Nd-YAG laser photocoagulation in brain can be reliably and safely effected.

Key words

Nd-YAG laser Interstitial irradiation Photocoagulation Rabbit brain 


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Copyright information

© Baillière Tindall 1992

Authors and Affiliations

  • Stanley W. Schatz
    • 1
  • Stephen G. Bown
    • 2
  • Douglas R. Wyman
    • 3
  • John T. Groves
    • 4
  • Brian C. Wilson
    • 3
  1. 1.McMaster University ClinicHamiltonCanada
  2. 2.The Rayne InstituteNational Medical Laser CentreLondonUK
  3. 3.Hamilton Regional Cancer CentreHamiltonCanada
  4. 4.H.G.H.-McMaster ClinicHamilton General HospitalHamiltonCanada

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