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Methotrexate therapy and liver fibrosis: are human prolyl hydroxylase and type IV collagen reliable and sensitive markers?

  • G. Tamaro
  • G. M. Danek
  • M. A. Mangiarotti
  • P. Tamaro
  • G. A. Zanazzo
Letters to the Editor

Key words

Methotrexate Liver fibrosis Human prolyl hydroxylase Type IV collagen 

References

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    Hopwood D, Nyfors A. Effect of methotrexate therapy in psoriatics on the Ito cells in liver biopsies, assessed by point-counting. J Clin Pathol 1976; 29:698.PubMedGoogle Scholar
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    Muller SA, Farrow GM, Martalock DL. Cirrhosis caused by methotrexate in the treatment of psoriasis. Arch Dermatol 1969; 100:523.PubMedCrossRefGoogle Scholar
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    Pihlajaniemi T, Myllyla R, Kivirikko KI. Prolyl 4-hydroxylase and its role in collagen synthesis. J Hepatol 1991; 13 [Suppl 3]:S2.CrossRefGoogle Scholar
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    Schuppan D. Connective tissue polypeptides in serum as parameters to monitor antifibrotic treatment in hepatic fibrogenesis. J Hepatol 1991; 13 [Suppl 3]:S17.CrossRefGoogle Scholar
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    Yoshida S, Bai Y, Muragaki et al. A sandwich immunoassay for human prolyl-hydroxylase using monoclonal antibody. Clin Chim Acta 1986; 160:35.CrossRefGoogle Scholar
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    Obata K, Iwata K, Ichida T, et al. One step sandwich enzyme immunoassay for human type IV collagen using monoclonal antibodies. Clin Chim Acta 1989; 181:299.CrossRefGoogle Scholar
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    Tamaro G, Moretti M, Marchi P, Mangiarotti MA, Pozzato G. Serum type IV collagen and prolyl hydroxylase levels: effect of gender and age. Clin Chim Acta 1994; 228:205.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • G. Tamaro
    • 1
  • G. M. Danek
    • 1
  • M. A. Mangiarotti
    • 1
  • P. Tamaro
    • 1
  • G. A. Zanazzo
    • 1
  1. 1.Laboratorio AnalisiIstituto per l’InfanziaTriesteItaly

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