Creatine kinase reaction rates in rat brain during chronic ischemia
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Creatine kinase reaction rates were measured by magnetisation transfer technique in the brain of healthy adult and aged rats and in the rats with mild or severe chronic cerebral ischemia. These measurements indicated that the rate constant of the creatine kinase reaction is significantly reduced in the case of chronic brain ischemia in aged rats. In contrast, occlusion of both carotid arteries in adult rats produced a slight increase in the reaction rate 4 weeks after occlusion. At the same time, corresponding conventional phosphorus magnetic resonance spectra showed negligible changes in signal intensities.
KeywordsCreatine kinase reaction rate Magnetisation transfer Rat brain chronic ischemia
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- Sauter A, Rudin M. Determination of creatine kinase kinetic parameters in rat brain by NMR magnetization transfer. J Biol Chem 1993; 682: 13166–71.Google Scholar
- Sharkey SW, Elspberger KJ, Murakami M, Apple FS. Canine myocardial creatine kinase isoenzyme response to coronary occlusion. Am J Physiol 1989; 256: 501–14.Google Scholar
- Morris GA, Freeman R. Selective excitation in Fourier transform nuclear magnetic resonance. J Magn Reson 1978; 29: 433–62.Google Scholar