Creatine kinase reaction rates in rat brain during chronic ischemia

  • V. MlynárikEmail author
  • S. Kašparová
  • T. Liptaj
  • D. Dobrota
  • J. Horecký
  • V. Belan


Creatine kinase reaction rates were measured by magnetisation transfer technique in the brain of healthy adult and aged rats and in the rats with mild or severe chronic cerebral ischemia. These measurements indicated that the rate constant of the creatine kinase reaction is significantly reduced in the case of chronic brain ischemia in aged rats. In contrast, occlusion of both carotid arteries in adult rats produced a slight increase in the reaction rate 4 weeks after occlusion. At the same time, corresponding conventional phosphorus magnetic resonance spectra showed negligible changes in signal intensities.


Creatine kinase reaction rate Magnetisation transfer Rat brain chronic ischemia 


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Copyright information

© Elsevier Science B. V. 1998

Authors and Affiliations

  • V. Mlynárik
    • 1
    Email author
  • S. Kašparová
    • 2
  • T. Liptaj
    • 2
  • D. Dobrota
    • 3
  • J. Horecký
    • 4
  • V. Belan
    • 1
  1. 1.Department of RadiologyDérer Faculty HospitalBratislavaSlovak Republic
  2. 2.NMR LaboratorySlovak Technical UniversityBratislavaSlovak Republic
  3. 3.Department of Biochemistry, Jessenius Faculty of MedicineComenius UniversityMartinSlovak Republic
  4. 4.Institute of Preventive and Clinical MedicineBratislavaSlovak Republic

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