Acta diabetologia latina

, Volume 22, Issue 3, pp 253–258 | Cite as

Serum cholesterol binding reserve percentage in diabetes mellitus

  • Ashim Ghatak
  • Kul Bhushan Bhatia
  • Ashok Chandra
  • Narinder Kumar Kapoor
Original Contributions

Summary

Serum cholesterol binding reserve percentage (SCBR%) in patients with diabetes mellitus (22.17±13.40%) was significantly lower than in controls (40.93±8.69%) (p<0.001). SCBR% of controls did not vary with age (age range 20.80 years). SCBR% declined significantly with increasing duration of diabetes. It also decreased with macrovascular complications and was lowest in multiple/fatal complications further corroborating the value of SCBR% as a risk indicator of atherogenesis. The relationship of SCBR% with treatment was very striking. All adequately controlled patients had a significantly higher SCBR% than those who were poorly controlled regardless of treatment modality and those adequately controlled on insulin had the highest SCBR%, which was close to that of normal controls.

Key-words

Diabetic patients Serum cholesterol binding 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bondjers G., Bjorkerud S.: Cholesterol transfer between arterial smooth muscle tissue and serum lipoproteinsin vitro — Artery1, 3–9, 1974.Google Scholar
  2. 2.
    Borreson A. L., Berg K., Dahlen G., Gillinas T., Ericson C.: Effect of gemfibrozil on human serum apolipoproteins and on serum reserve cholesterol binding capacity (SRCBC) — Artery9, 77–86, 1981.Google Scholar
  3. 3.
    Borreson A. L., Berg K.: Serum reserve cholesterol binding capacity (SRCBC): the relative importance of lipoprotein classes — Artery9, 96–119, 1981.Google Scholar
  4. 4.
    Chandra A., Gupta S., Bhatia K. B., Kapoor N. K.: Serum cholesterol binding reserve in young myocardial infarction. Proceedings of the World Congress on Coronary Heart Disease, Bombay, Feb. 1982.Google Scholar
  5. 5.
    Chandra R., Singh R., Kumar S., Srivastava D. K.: Serum cholesterol binding reserve in some coronary artery disease risk cases — Indian Heart J.32, 355, 1980.PubMedGoogle Scholar
  6. 6.
    Chandra R., Singh R., Srivastava D. K., Gupta A. K.: Study of serum cholesterol binding reserve in some coronary artery disease risk cases — J.A.P.I.30, 601, 1982.Google Scholar
  7. 7.
    Gupta S.: Serum cholesterol binding reserve. A study of premature atherosclerosis in young patients with myocardial infarction. Thesis submitted to Lucknow University, 1981.Google Scholar
  8. 8.
    Hsia S. L., Chao Y.-S., Hennekens C. H., Reader W. B.: Decreased serum cholesterol-binding reserve in premature myocardial infarction — Lancetii, 1000, 1975.CrossRefGoogle Scholar
  9. 9.
    Hsia S. L., Fishman L. M., Briese F. W., Chistakis G., Burr J., Bricker L. A.: Decreased serum cholesterol binding reserve in diabetes mellitus — Diabetes Care1, 89–93, 1978.PubMedCrossRefGoogle Scholar
  10. 10.
    Marble A., Camerini-Davalos R.: Clinical experience with sulfonylurea compounds in diabetes — Ann. N.Y. Acad. Sci.71, 293–248, 1957.CrossRefGoogle Scholar
  11. 11.
    National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance — Diabetes28, 1039, 1979.Google Scholar
  12. 12.
    Stein Y., Glanceaud M. C., Fainaru M., Stein O.: The removal of cholesterol from aortic smooth muscle cells in culture and landschutz ascites cells by fractions of human high-density apolipoprotein — Biochim. biophys. Acta (Amst.)380, 106, 1975.Google Scholar
  13. 13.
    Zlatkis A., Zake B., Boyle A. J.: A new method for the direct determination of serum cholesterol — J. Lab. clin. Med.41, 486, 1953.PubMedGoogle Scholar

Copyright information

© Casa Editrice «il Ponte» 1985

Authors and Affiliations

  • Ashim Ghatak
    • 1
  • Kul Bhushan Bhatia
    • 1
  • Ashok Chandra
    • 1
  • Narinder Kumar Kapoor
    • 1
  1. 1.Division of Biochemistry, Central Drug Research Institute, Department of MedicineK.G. Medical CollegeLucknow

Personalised recommendations