Acta diabetologia latina

, Volume 25, Issue 2, pp 155–160 | Cite as

The effects of muscular exercise on glucose, free fatty acids, alanine and lactate in type I diabetic subjects in relation to metabolic control

  • Maria Donatelli
  • Salvatore Verga
  • Vincenza Russo
  • Caterina Terrizzi
  • Maria Luisa Bucalo
  • Antonina Scarpinato
  • Maria Vaccaro
  • Giovanni Cerasola
Original Contributions

Summary

Metabolic effects of muscular exercise were studied in eleven subjects with type I diabetes mellitus during poor metabolic control, and again during good metabolic control, and in ten healthy control subjects. All the subjects were submitted to a submaximal gradual triangular test on an electrically braked bicycle ergometer; glucose, FFA, alanine and lactate were measured at rest, and after exercise. In poorly controlled patients, glucose and FFA were unchanged after exercise, whereas blood alanine and lactate increased by a percentage similar to that of the controls, and well-controlled diabetic patients. Baseline alanine concentrations were lower and lactate concentrations higher than in the controls and well-controlled patients. After adequate metabolic control was achieved, in the well-controlled diabetic patients a normalization of pre-exercise alanine and lactate levels and a decrease in blood glucose and FFA after exercise was observed.

Key-words

Alanine FFA Glucose Lactate Muscular exercise Type I diabetes mellitus 

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Copyright information

© Casa Editrice «il Ponte» 1988

Authors and Affiliations

  • Maria Donatelli
    • 1
  • Salvatore Verga
    • 1
  • Vincenza Russo
    • 1
  • Caterina Terrizzi
    • 1
  • Maria Luisa Bucalo
    • 1
  • Antonina Scarpinato
    • 1
  • Maria Vaccaro
    • 1
  • Giovanni Cerasola
    • 1
  1. 1.Istituto di Clinica Medica, Cattedra di Clinica Medica BaseUniversità degli Studi di PalermoPalermoItaly

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