Acta diabetologia latina

, Volume 26, Issue 2, pp 155–162

Dietary-induced thermogenesis in obesity. Response to mixed and carbohydrate meals

  • Carlo De Palo
  • Cinzia Macor
  • Nicola Sicolo
  • Roberto Vettor
  • Cesare Scandellari
  • Giovanni Federspil
Article

Summary

The possibility that dietary-induced thermogenesis may be decreased in obesity has been proposed in recent years. However, the results of human studies so far obtained are conflicting. The present research was undertaken in order to clarify this question. We studied postprandial thermogenesis induced by ingestion of a mixed meal and of a carbohydrate mixture in 15 normal and 12 obese subjects. Blood glucose and plasma insulin levels were measured at the same time. The data obtained have shown that the mean resting metabolic rate (RMR) expressed as a function of body weight3/4, is almost the same in obese as in normal-weight subjects (0.115±0.018vs 0.133±0.021 kj/min/kg3/4, respectively). Moreover, the increment of mixed-meal induced thermogenesis (MM-IT) was 48±22% in normal and −0.8±12% in obese subjects, respectively (p<0.01). Carbohydrate induced thermogenesis (CHO-IT) appeared slightly higher in normal-weight than in obese subjects (159±66vs 98±46). After carbohydrate ingestion we observed a higher glycemic and insulinemic response in obesity. These results indicate that thermogenesis induced by ingestion of food is reduced in obese subjects; they are also compatible with the idea that insulin resistance could play a role in this phenomenon.

Key-words

Carbohydrate ingestion Energy expenditure Glucose Insulin Mixed meal Obesity Thermogenesis 

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References

  1. 1.
    Bessard T., Schutz Y., Jéquier E.: Energy expenditure and postprandial thermogenesis in obese women before and after weight loss — Amer. J. clin. Nutr.38, 680–693, 1983.PubMedGoogle Scholar
  2. 2.
    Contaldo F., Reed L. A., Laviano A., Coltorti A., Pacioni D., Borrelli R., Mancini M.: Postprandial thermogenesis and meal lipid composition in human obesity — Europ. J. clin. Invest.14, 2, 1984.Google Scholar
  3. 3.
    Felig P., Cunningham J., Levitt M., Hendler R., Nadel E.: Energy expenditure in obesity in fasting and postprandial state — Amer. J. Physiol.244, E45-E51, 1983.PubMedGoogle Scholar
  4. 4.
    Golay A., Schutz J., Meyer H. U., Thiébaud D., Curchod B., Maeder E., Felber J. P., Jéquier E.: Glucose induced thermogenesis in nondiabetic and diabetic obese subjects — Diabetes31, 1023–1028, 1982.PubMedGoogle Scholar
  5. 5.
    Jéquier E.: Métabolisme energétique. — Encyclopédie Médico Chirurgicale, Nutrition 10371, A 10, 11, 1980; p. 1.Google Scholar
  6. 6.
    Jéquier E., Schutz Y.: New evidence for thermogenic defect in human obesity — Int. J. Obesity9 (Suppl. 2), 1–7, 1985.Google Scholar
  7. 7.
    Jung R. T., Shetty P. S., James W. P. T., Barrand M., Callingham B. A.: Reduced thermogenesis in obesity — Nature (Lond.)279, 322–323, 1979.CrossRefGoogle Scholar
  8. 8.
    Kaplan M. L., Leveille G. A.: Calorigenic response in obese and nonobese women — Amer. J. clin. Nutr.29, 1108–1113, 1976.PubMedGoogle Scholar
  9. 9.
    Kleiber M.: The fire of life. Huntington, New York, 1975; p. 180–181.Google Scholar
  10. 10.
    Nair K. S., Halliday D., Garrow J. S.: Thermic response to isoenergetic protein, carbohydrate or fat meals in lean and obese subjects — Clin. Sci.65, 307–312, 1983.PubMedGoogle Scholar
  11. 11.
    Ravussin E., Burnard B., Schutz Y., Jéquier E.: Twenty-four hour energy expenditure and resting metabolic rate in obese, moderately obese, and control subjects — Amer. J. clin. Nutr.35, 366–373, 1982.Google Scholar
  12. 12.
    Rothwell N. J., Stock M. J.: Regulation of energy balance — Ann. Rev. Nutr.1, 235–256, 1981.CrossRefGoogle Scholar
  13. 13.
    Schutz Y., Golay A., Felber J.-P., Jéquier E.: Decreased glucose-induced thermogenesis after weight loss in obese subjects: a predisposing factor for relapse of obesity — Amer. J. clin. Nutr.39, 380–387, 1984.PubMedGoogle Scholar
  14. 14.
    Sharief N. N., Macdonald I.: Differences in dietary-induced thermogenesis with various carbohydrates in normal and overweight men — Amer. J. Nutr.35, 267–272, 1982.Google Scholar
  15. 15.
    Shetty P. S., Jung R. T., James W. P. T., Barrand M. A., Callingham B. A.: Postprandial thermogenesis in obesity — Clin. Sci.60, 519–525, 1981.PubMedGoogle Scholar
  16. 16.
    Wang C. C., Strouse S.: Studies on the metabolism of obesity. III. The specific dynamic action of food — Arch. intern. Med.34, 573–583, 1924.Google Scholar
  17. 17.
    Welle S. L., Campbell R. G.: Normal thermic effect of glucose in obese women — Amer. J. clin. Nutr.37, 87–92, 1983.PubMedGoogle Scholar

Copyright information

© Casa Editrice Il Ponte 1989

Authors and Affiliations

  • Carlo De Palo
    • 1
  • Cinzia Macor
    • 1
  • Nicola Sicolo
    • 1
  • Roberto Vettor
    • 1
  • Cesare Scandellari
    • 1
  • Giovanni Federspil
    • 1
  1. 1.Istituto di Semeiotica Medica, Patologia Medica IIIUniversità degli Studi di PadovaPadovaItaly

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